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Evidenciando el trabajo: implementación de la profilaxis preexposición al VIH y la dosificación a demanda en

Martin Holt¹, Kari Lancaster², Tim Rhodes³

¹Centre for Social Research in Health, UNSW Sydney, Australia.

Social science & medicine (1982)

|December 20, 2025

Resumen

Partes interesadas

Área de la Ciencia:

Salud Pública
Ciencia de la Implementación
Prevención del VIH

Sus antecedentes:

La profilaxis preexposición al VIH (PrEP) se usó inicialmente con dosificación diaria en Australia.
La comprensión de la implementación de la PrEP y los cambios a la dosificación a demanda es limitada.

Objetivo del estudio:

Explorar cómo las partes interesadas implementaron la PrEP y el papel del 'trabajo de evidencia'.
Comprender la movilización de la evidencia local en la práctica de la PrEP.

Principales métodos:

21 entrevistas con partes interesadas clave (2021-2022).
Las partes interesadas representaron la investigación, la práctica clínica, la política, la promoción de la salud y la participación de la comunidad.
El análisis se centró en cómo se utilizó la evidencia para comprender y evaluar el rendimiento de la PrEP.

Principales resultados:

Las partes interesadas participaron en un 'trabajo de evidencia' de traducción, autorización y localización.
La generación de evidencia (nacional, local, entre pares, experta) aseguró la seguridad y la eficacia.
El reconocimiento de la dosificación a demanda creció, apartándose de las pautas clínicas estrictas.

Conclusiones:

El 'trabajo de evidencia' es crucial para la implementación de la PrEP y la adaptación de los regímenes de dosificación.
Facilitar la localización de la evidencia, especialmente con nuevos prescriptores, puede apoyar una implementación más amplia de la PrEP.
Compartir la evidencia de pares, pacientes y expertos es clave para la adopción de la PrEP a demanda.

Palabras clave:

Dosificación Evidencia Expertos Pautas Profilaxis preexposición al VIH

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