Video Experimental Relacionado

Updated: Jan 8, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Nanocilindros de hidroxiapatita cargados con ácido chichórico remodelan el microambiente inmunitario para mejorar la

Xiaolong Lin¹, Chenlong Liu², Yuqing Lei³

¹Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, 310000, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|December 20, 2025

Abstracto

Background:

Bone defect regeneration requires both osteogenic stimulation and immunomodulation of the local microenvironment.

Purpose:

This study aimed to develop a cichoric acid-loaded hydroxyapatite nanocomposite (CA@HAp) that integrates metabolic and immunological regulation to promote bone repair.

Study Design:

The efficacy of CA@HAp was evaluated in a rat femoral defect model.

Methods:

Cichoric acid (CA) was electrostatically adsorbed onto nano-hydroxyapatite to form CA@HAp, which exhibited stable properties and pH-dependent release. Its effects on macrophage metabolism, polarization, cytokine secretion, and osteogenic signal expression were analyzed.

Results:

CA@HAp effectively reprogrammed macrophage metabolism, shifting polarization from pro-inflammatory M1 to pro-regenerative M2. This transition suppressed inflammatory cytokines (IL-12, IL-6, NLRP3) and upregulated anti-inflammatory and osteogenic factors (IκBα, BMP2, OPN, OCN, RUNX2). Furthermore, CA@HAp promoted angiogenesis and significantly enhanced osteogenesis, bone mineral density, and vascularized bone regeneration compared to control groups.

Conclusion:

CA@HAp serves as a multifunctional immuno-osteogenic platform that couples metabolic reprogramming with macrophage polarization, presenting a promising strategy for bone defect regeneration.

Palabras clave:

Regeneración de defectos óseos Nanocompuesto de hidroxiapatita cargado con ácido chichórico Regulación inmunometabólica Polarización de macrófagos Osteogénesis Regeneración ósea vascularizada

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