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ARN no codificantes largos en la biosíntesis de metabolitos secundarios de plantas: mecanismos y aplicaciones

Hongwei Li¹, Ning Yang², Hongbin Zhang³

¹Department of Medical Instrumental Analysis, Zunyi Medical University, Zunyi, Guizhou 563099, China; Key Laboratory for Cancer Prevention and Treatment of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou 563099, China; Department of Soil and Crop Sciences, Texas A&M University, College Station, TX 77843, USA.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|December 20, 2025

Resumen

Los ARN no codificantes largos (lncRNA) regulan la biosíntesis de metabolitos secundarios de plantas, ofreciendo potencial para el desarrollo de nuevos fármacos. La comprensión de estos lncRNA proporciona información sobre el descubrimiento de fármacos de productos naturales.

Área de la Ciencia:

Biología vegetal; Genética molecular; Bioquímica

Sus antecedentes:

Los metabolitos secundarios de las plantas son cruciales para la tolerancia al estrés y tienen aplicaciones en productos farmacéuticos, alimentos y cosméticos.
Los ARN no codificantes largos (lncRNA) son reguladores clave de la biosíntesis de metabolitos secundarios.
Los roles regulatorios y los mecanismos de los lncRNA en el metabolismo secundario de las plantas no se comprenden completamente.

Objetivo del estudio:

Investigar las funciones regulatorias de los lncRNA de plantas en la biosíntesis de metabolitos secundarios.
Ofrecer nuevas perspectivas para la investigación en el metabolismo secundario de las plantas.
Identificar estrategias para el desarrollo de nuevos fármacos derivados de plantas.

Principales métodos:

Revisión de literatura de artículos académicos de las principales bases de datos científicas (Web of Science, Google Scholar, PubMed, etc.).
Las palabras clave incluyeron "plant lncRNA", "secondary metabolites", "natural products", "biosynthesis" y clases específicas de metabolitos (terpenoides, flavonoides, alcaloides).

Principales resultados:

Los ARN no codificantes largos (lncRNA) regulan el crecimiento, desarrollo y respuestas al estrés de las plantas.
Los lncRNA están involucrados en la biosíntesis de importantes metabolitos secundarios como terpenoides, flavonoides y alcaloides.
Estos metabolitos muestran un potencial terapéutico significativo para diversas enfermedades.

Conclusiones:

Los lncRNA están implicados en la biosíntesis y biotransformación de metabolitos secundarios de plantas.
La manipulación de lncRNA puede conducir al desarrollo de nuevos fármacos a partir de productos naturales.
La investigación adicional puede beneficiar significativamente la salud humana a través del descubrimiento de fármacos basados en plantas.

Palabras clave:

Función biológica Biosíntesis Medicina herbal LncRNA Mecanismo molecular Metabolito secundario

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