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Updated: Jan 8, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Guía metodológica sobre desafíos y soluciones prácticas en bioanálisis para la cuantificación precisa de modalidades

Devendra Kumar1, Manish Sharma2, Neerja Trivedi3

  • 1Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, USA.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
|December 20, 2025
PubMed
Resumen

Esta revisión ofrece una guía práctica para cuantificar oligonucleótidos terapéuticos mediante cromatografía líquida-espectrometría de masas (LC-MS). Aborda los desafíos analíticos para garantizar un bioanálisis fiable para el desarrollo de fármacos.

Palabras clave:
ColumnasReactivos de emparejamiento iónicoLC-MS/MSUnión no específicaOligonucleótidosFarmacocinéticaSPE

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