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Updated: Jan 8, 2026
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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
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Interacción electro-microbiana en el eje intestino-cerebro: un paradigma emergente para la modulación de la
Jingwen Liang1, Xiunan Li2, Chunyang Mao3
1College of Pharmaceutical Sciences & Key Laboratory of Ministry of Education in Protection and Utilization of Medicinal Resources of Liupanshan Area, Ningxia Medical University, Yinchuan 750004, Ningxia, China.
Current opinion in pharmacology
|December 20, 2025
Resumen
La estimulación del nervio vago (VNS) impacta la microbiota intestinal, lo que influye en la función cerebral. Los productos microbianos también regulan la actividad del nervio vago, ofreciendo nuevos objetivos terapéuticos para los trastornos del sistema nervioso central.
Área de la Ciencia:
- Neurociencia
- Microbiología
- Gastroenterología
Sus antecedentes:
- Los trastornos del sistema nervioso central (SNC) requieren tratamientos novedosos.
- El eje intestino-cerebro implica una comunicación bidireccional a través del nervio vago.
- La estimulación del nervio vago (VNS) se utiliza para la epilepsia y la depresión.
Objetivo del estudio:
- Revisar los mecanismos de la VNS sobre la microbiota intestinal.
- Explorar la retroalimentación microbiana sobre la actividad del nervio vago.
- Comprender la comunicación cruzada de la interfaz intestino-cerebro para terapias novedosas.
Principales métodos:
- Revisión sistemática de la literatura existente.
- Análisis de vías neurales, inmunes y metabólicas.
- Examen de los efectos de la VNS en la composición y función de la microbiota intestinal.
Principales resultados:
- La VNS modula la microbiota intestinal, afectando la progresión de la enfermedad.
- Los metabolitos de la microbiota intestinal influyen en la actividad del nervio vago.
- La señalización bidireccional ocurre a través de rutas neurales, inmunes y metabólicas.
Conclusiones:
- Las interacciones entre la VNS y la microbiota intestinal ofrecen potencial terapéutico.
- La focalización de la interfaz intestino-cerebro puede generar nuevos tratamientos para los trastornos del SNC.
- Comprender esta comunicación cruzada es clave para futuras intervenciones.
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