Modificaciones postraduccionales mediadas por Sirtuina 5 como un enfoque terapéutico prometedor para atenuar las...

Liver diseases, a cluster of diseases such as acute liver injury, chronic hepatitis, liver fibrosis, and hepatoma, pose a serious threat to public health. There is pressing clinical need to develop multiple effective approaches for the treatment of liver diseases. Sirtuin 5 (SIRT5), a member of the sirtuin family of NAD⁺-dependent deacylases, primarily regulates desuccinylation, demalonylation, and deglutarylation modifications. Through these activities, SIRT5 participates in key biological processes such as cellular growth, proliferation, and apoptosis, and affects the pathogenesis of various diseases. However, the mechanisms of SIRT5 contributing to liver diseases, particularly liver fibrosis, remain incompletely understood. Dysregulation of SIRT5 has been implicated in promoting the liver diseases progression by metabolism imbalance, excess mitochondrial oxidative stress, pro-inflammatory cytokines release, and abnormal autophagy. Given its unique post-translational modification activity and biological and physiological functions, SIRT5 has recently emerged as a promising therapeutic target against liver diseases. In this review, we summarize the current knowledge regarding SIRT5 in liver diseases to provide a comprehensive understanding of the research progress of SIRT5 in liver diseases.