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Bronquiectasias y rasgos tratables: el viaje del concepto a la práctica clínica
Pau Marrades1, Alessandro De Angelis2, Alessandra Iorfida3
1Respiratory Department, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERES, Barcelona, Spain.
Respiratory medicine
|December 20, 2025
Resumen
El enfoque de rasgos tratables (TT) ofrece una estrategia de medicina de precisión para la bronquiectasias, identificando y dirigiendo características específicas del paciente para mejorar los resultados. Este marco tiene como objetivo personalizar el tratamiento para obtener mejores resultados centrados en el paciente.
Área de la Ciencia:
- Medicina Pulmonar
- Medicina de Precisión
- Enfermedades Respiratorias
Sus antecedentes:
- Las bronquiectasias son una enfermedad crónica de las vías respiratorias con opciones de tratamiento limitadas.
- El enfoque de rasgos tratables (TT) se centra en la medicina personalizada para afecciones complejas.
- TT identifica características medibles y modificables del paciente.
Objetivo del estudio:
- Actualizar el marco de rasgos tratables (TT) para las bronquiectasias.
- Revisar la literatura actual y compararla con otras enfermedades pulmonares.
- Explorar herramientas de diagnóstico, monitorización y terapias emergentes dentro del marco TT.
Principales métodos:
- Búsqueda exhaustiva de literatura en PubMed hasta el 1 de julio de 2025.
- Inclusión de estudios clínicos y traslacionales.
- Comparación de TT en bronquiectasias con otras enfermedades pulmonares.
Principales resultados:
- Los pacientes con bronquiectasias a menudo presentan múltiples rasgos (esputo, infección, exacerbaciones, inflamación, comorbilidades).
- Los tratamientos actuales abordan algunos rasgos, pero la evidencia es limitada.
- Las terapias emergentes dirigidas a las vías neutrofílicas son prometedoras para endotipos específicos.
Conclusiones:
- El enfoque TT significa un cambio hacia la medicina de precisión en las bronquiectasias.
- Esta estrategia tiene el potencial de mejorar los resultados y el pronóstico del paciente.
- La investigación futura debe validar el enfoque TT a través de estudios clínicos, considerando las preferencias del paciente.
Palabras clave:
BronquiectasiasComorbilidadesHeterogeneidad de la enfermedadEndotiposFenotiposMedicina de precisiónRasgos tratablesMás Videos Relacionados
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