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Nanomedicina de doble función TA@CaCO3 dirigida a la sensibilidad a la peroxidación lipídica de los macrófagos M2 en
Qin Zhang1,2, Ziliang Dong3, Yanglin Wu1,2
1Department of Orthopedics, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou, 215000, Jiangsu, P. R. China.
Abstract:
Rheumatoid arthritis (RA) is a globally prevalent autoimmune musculoskeletal disease that requires early-stage treatment. Initially, patients with RA exhibit elevated reactive oxygen species (ROS) levels and acidic conditions within the articular spaces. These two factors synergistically promote lipid peroxidation in M2 macrophages and lead to increased inflammation. Our work was then designed to engineer a multifunctional nanomedicine that targets the increased lipid peroxidation sensitivity of M2 macrophages. We successfully synthesized a calcium carbonate (CaCO3)-based nanomedicine via a biomineralization approach involving tannic acid (TA) and poly(ethylene glycol)-b-poly(glutamic acid). The TA@CaCO3 nanomedicine exhibited superior ability to neutralize acidity and scavenge ROS both in vitro and in vivo, effectively enhancing the lipid peroxidation resistance of M2 macrophages. Therefore, this nanomedicine significantly protected M2 macrophages and ameliorated the symptoms of arthritis, achieving therapeutic efficacy comparable to that of conventional methotrexate therapy. This study proposes a therapeutic strategy for regulating immunity by improving the pathological microenvironment within the joint cavity in rheumatoid arthritis patients.
