Video Experimental Relacionado

Updated: Jan 8, 2026

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Published on: May 12, 2020

Carga mundial, factores de riesgo, organismos causales y patrones de susceptibilidad a los antibióticos en la

Rohan Bir Singh¹, Uday Pratap Singh Parmar², Fasika Woreta³

¹Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, MA, USA; Division of Ophthalmology and Visual Sciences, Adelaide Medical School, University of Adelaide, South Australia, Australia.

The ocular surface

|December 21, 2025

Resumen

La queratitis bacteriana (QB) representa casi la mitad de todos los casos de queratitis infecciosa a nivel mundial. Las estrategias de prevención deben centrarse en la higiene en caso de traumatismos y lentes de contacto, con terapias dirigidas para SARM y Pseudomonas.

Área de la Ciencia:

Oftalmología; Enfermedades Infecciosas; Microbiología

Sus antecedentes:

La queratitis infecciosa es una causa importante de deterioro visual en todo el mundo.
La queratitis bacteriana (QB) es un subtipo importante, que requiere la comprensión de su carga mundial y sus características.

Objetivo del estudio:

Revisar sistemáticamente y meta-analizar la prevalencia mundial de QB.
Identificar las causas microbianas comunes, los factores de riesgo y los patrones de susceptibilidad a los antibióticos de la QB.

Principales métodos:

Búsqueda sistemática en las principales bases de datos (PubMed, Scopus, etc.) hasta julio de 2022.
Inclusión de estudios observacionales con QB microbiológicamente confirmada y datos de susceptibilidad a los antibióticos.
Meta-análisis de efectos aleatorios para la prevalencia combinada y síntesis descriptiva de factores de riesgo y susceptibilidad.

Principales resultados:

La prevalencia mundial combinada de QB fue del 44% (IC del 95%: 39-49%), con variaciones regionales significativas.
Las bacterias Grampositivas predominaron (72%), con especies clave que incluyen Staphylococcus epidermidis, Streptococcus pneumoniae, Staphylococcus aureus y Pseudomonas aeruginosa.
Los principales factores de riesgo fueron los traumatismos (44%) y el uso de lentes de contacto (23%); se observó una alta susceptibilidad a la vancomicina (Grampositivas) y a los aminoglucósidos/cefalosporinas (Gramnegativas), pero se observó una menor susceptibilidad a las fluoroquinolonas y tasas significativas de SARM (~20%).

Conclusiones:

La queratitis bacteriana representa una proporción sustancial de los casos de queratitis infecciosa a nivel mundial.
Es crucial enfatizar la prevención de traumatismos y la mejora de la higiene de las lentes de contacto.
Las estrategias de tratamiento empírico deben considerar la cobertura para SARM y Pseudomonas aeruginosa debido a los patrones de resistencia.

Palabras clave:

queratitis bacteriana prevalencia factores de riesgo resistencia a los antibióticos tratamiento prevención oftalmología microbiología enfermedades infecciosas

Más Videos Relacionados

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Videos de Conceptos Relacionados

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

Development of Antibiotic Resistance

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

Antibiotic Selection

Antibiotic Selection

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

Infection

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...

Gene Regulation in Microbial Communities: Quorum Sensing

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...