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Estimulación cerebral no invasiva centrada en la persona para trastornos neurológicos y mentales relacionados con el

Sa Zhou¹, Corey J Keller², Nai-Feng Chen¹

¹Department of Psychiatry and Behavioral Sciences, Stanford University, 1070 Arastradero road, Palo Alto, CA 94304, USA.

Neuroscience and biobehavioral reviews

|December 21, 2025

Resumen

Los protocolos personalizados de estimulación cerebral no invasiva (NIBS) pueden mejorar el tratamiento de los trastornos neurológicos y mentales relacionados con el envejecimiento al adaptar la estimulación a las necesidades individuales del paciente. Este marco mejora la eficacia de la NIBS al abordar la variabilidad del paciente.

Área de la Ciencia:

Neurociencia
Gerontología
Psicología Clínica

Sus antecedentes:

La estimulación cerebral no invasiva (NIBS) muestra promesa para los trastornos neurológicos y mentales relacionados con el envejecimiento (ANMD).
Los beneficios clínicos de la NIBS varían debido a la heterogeneidad de los pacientes.
Las estrategias actuales de personalización para NIBS están aisladas y carecen de un marco sistemático.

Objetivo del estudio:

Proponer un marco multidimensional para el diseño de protocolos de NIBS centrada en la persona.
Dirigirse sistemáticamente a las diferencias interindividuales y las variaciones intraindividuales en los pacientes.
Mejorar los recursos neuronales para mejorar la cognición, el estado de ánimo y las funciones motoras en los ANMDs.

Principales métodos:

Revisión sistemática de las estrategias actuales de personalización y la eficacia de la NIBS personalizada en ANMD.
Presentación de un marco conceptual multidimensional para la NIBS centrada en la persona.
Marco operativo para personalizar el objetivo y la dosis de NIBS utilizando neuroimagen, monitorización en bucle cerrado, modelado de la relación dosis-respuesta e intervenciones complementarias.

Principales resultados:

Una revisión sistemática identificó limitaciones en las estrategias actuales de personalización de NIBS.
Se conceptualizó un nuevo marco multidimensional para la NIBS centrada en la persona.
Se propuso un marco operativo para la personalización sistemática del objetivo y la dosis de NIBS.

Conclusiones:

El marco propuesto puede guiar el desarrollo de protocolos de NIBS centrada en la persona.
Se espera que este enfoque mejore la eficacia clínica de la NIBS en los ANMD.
La NIBS centrada en la persona tiene el potencial de mejorar los resultados del tratamiento en poblaciones de edad avanzada.

Palabras clave:

Trastornos neurológicos y mentales relacionados con el envejecimiento Estimulación cerebral en bucle cerrado Modelado de la relación dosis-respuesta Segmentación guiada por neuroimagen Estimulación cerebral no invasiva centrada en la persona Neuromodulación personalizada

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