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Síntesis ultrarrápida de α-aminofosfonatos utilizando un disolvente eutéctico profundo ternario en agua
Najmedin Azizi1, Navid Habibnejad2, Nasim Nourazar2
1Haghayegh Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335‑186, Tehran, Iran. azizi@ccerci.ac.ir.
Scientific reports
|December 21, 2025
Resumen
Un novedoso disolvente eutéctico profundo ternario (TDES) facilita la síntesis rápida y sostenible de α-aminofosfonatos. Este enfoque de química verde ofrece altos rendimientos y reutilización del catalizador para una síntesis orgánica eficiente.
Área de la Ciencia:
- Química Verde; Síntesis Orgánica; Catálisis
Sus antecedentes:
- Los α-aminofosfonatos son andamios privilegiados medicinalmente cruciales.
- Se necesitan métodos sintéticos eficientes y sostenibles para su producción.
Objetivo del estudio:
- Desarrollar una síntesis rápida y sostenible de α-aminofosfonatos.
- Utilizar un disolvente eutéctico profundo ternario (TDES) como catalizador.
Principales métodos:
- Síntesis de un catalizador TDES de urea/SnCl2/HCl.
- Reacción de TDES con diversos sustratos en agua.
- Caracterización mediante espectroscopia de 119Sn-RMN, 13C-RMN y UV-VIS.
- Asignación estereoquímica mediante espectroscopia de RMN.
Principales resultados:
- Se logró la síntesis de diversos α-aminofosfonatos en 48-120 segundos.
- Se obtuvieron rendimientos cuantitativos con alta selectividad.
- Se demostró la reutilización del catalizador durante al menos tres ciclos.
- Se confirmó la estructura del catalizador y el seguimiento de la reacción mediante espectroscopia.
Conclusiones:
- El protocolo promovido por TDES ofrece una ruta altamente eficiente, rápida y sostenible hacia los α-aminofosfonatos.
- Las propiedades del catalizador lo hacen adecuado para la química de procesos a gran escala.
- Este método representa un avance significativo en la síntesis orgánica verde.
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