Video Experimental Relacionado

Updated: Jul 23, 2026

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

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CX3CR1: una diana potencial específica de microglia para imagenología por PET en la enfermedad de Alzheimer y

Hongzhi Yang¹, Yanli Wang², Yulong Xu²

¹Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Frontiers in pharmacology

|December 22, 2025

Abstract:

Microglia are the resident immune cells of the central nervous system (CNS), playing a crucial role in maintaining brain homeostasis and mediating neuroimmune responses. The chemokine receptor CX3CR1, predominantly expressed on microglia, regulates microglial function via interactions with its neuronal ligand CX3CL1. The CX3CR1-CX3CL1 signaling exhibits complex, context-dependent roles in neurodegenerative diseases. In Alzheimer's disease (AD) and Parkinson's disease (PD) animal models, CX3CR1 deficiency shows paradoxical outcomes, attenuating or exacerbating amyloid-β (Aβ) and tau pathologies in AD, while consistently worsening α-synuclein-induced neurodegeneration in PD. Although CX3CR1 emerges as a promising therapeutic and diagnostic target, its complex role in microglial dynamics remains incompletely understood. Positron emission tomography (PET) imaging provides a powerful, noninvasive method for investigating biological processes in vivo. There is an urgent need to develop and validate new PET tracers targeting microglial CX3CR1 in the CNS, further offering new opportunities for the diagnosis and treatment of neuroinflammation-associated neurodegenerative diseases.

Palabras clave:

enfermedad de Alzheimer CX3CR1 enfermedad de Parkinson microglía trazadores de tomografía por emisión de positrones

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