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Updated: Jan 8, 2026
Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
Construcción y Validación de un Modelo de Predicción de Riesgo de Lesión Miocárdica Inducida por Sepsis
Yi Gou1, Yun Cong2, Zhen-Zhen Guo3
1Emergency Trauma Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People's Republic of China.
Background:
Sepsis patients face a high risk of myocardial injury, which increases the risk of death. Therefore, the rapid and accurate assessment of myocardial injury risk is crucial for improving prognosis.
Objective:
To construct and validate a risk prediction model for sepsis-induced myocardial injury (SMCI).
Methods:
Patients were randomly assigned to a training cohort and an internal validation cohort in a 7:3 ratio. Least Absolute Shrinkage and Selection Operator (LASSO) regression and multivariate logistic regression were used to identify independent predictors for the construction of a nomogram. The model's discrimination, calibration, and clinical applicability were evaluated using area under curve (AUC), Hosmer-Lemeshow tests, decision curve analysis (DCA) and clinical impact curve (CIC). Meanwhile, internal validation was conducted.
Results:
The study included 370 patients, with 262 in the training cohort and 108 in the validation cohort. 3 independent risk factors were identified, including Log myoglobin (Myo), Log B-type natriuretic peptide (BNP), and Log interleukin-6 (IL-6) and a nomogram incorporating these factors was constructed. The AUC in the training and validation cohorts was 0.856 and 0.853, respectively. The Hosmer-Lemeshow test indicated good calibration in both cohorts, while DCA and CIC demonstrated strong clinical applicability.
Conclusion:
The nomogram based on Log Myo, Log BNP, and Log IL-6 may serve as a practical tool for the early identification of high-risk patients by facilitating the rapid calculation of SMCI risk.
