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Células CAR-NK para cánceres ginecológicos: remodelación del microambiente inmunitario y estrategias

Mingyao Huang^1,2, Siyang Wang³, Huiyan Huang⁴

¹School of Basic Medicine, Putian University, Putian, Fujian, China.

Frontiers in immunology

|December 22, 2025

Abstract:

Gynecological malignancies, including ovarian, cervical, and endometrial cancers, represent a substantial global health burden, contributing significantly to morbidity and mortality among women. Despite advancements in therapeutic strategies, outcomes for many patients remain suboptimal due to challenges such as late-stage detection and resistance to standard treatments. The advent of chimeric antigen receptor (CAR)-engineered natural killer (NK) cells has introduced a cutting-edge immunotherapy option. This review provides an in-depth exploration of the development of CAR-NK cells, emphasizing their sources, design methodologies, and applications in managing gynecological cancers. It also examines current obstacles and outlines innovative strategies to improve the effectiveness and safety of CAR-NK cell-based therapies. Furthermore, we discuss prospective advancements, highlighting the importance of ongoing research and technological innovation to unlock the full potential of CAR-NK cells in the fight against gynecological cancers.

Palabras clave:

Células CAR-NK cánceres ginecológicos inmunomodulación inmunoterapia microambiente inmunitario tumoral

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