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Factores de riesgo de síndrome de activación de macrófagos en la artritis idiopática juvenil sistémica: una revisión

Shihao Li^1,2,3, Xin Wu^1,2,3, Shuolan Jing^1,2,3

¹Division of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China.

Frontiers in pediatrics

|December 22, 2025

Abstracto

Background:

Macrophage activation syndrome (MAS) is among the most life-threatening complications of systemic juvenile idiopathic arthritis (sJIA). Early identification of risk factors is critical for reducing mortality. However, existing evidence is markedly heterogeneous and lacks quantified, comparable, and clinically translatable conclusions.

Methods:

We systematically searched PubMed, Web of Science, EMBASE, and Chinese databases, including China national knowledge infrastructure (CNKI), Wanfang, VIP, and Chinese biomedical literature database (CBM), from inception to 1 July 2025, for case-control studies investigating risk factors for MAS in sJIA. Two investigators independently screened studies, extracted data, and assessed study quality. Meta-analyses were performed using RevMan 5.3 and Stata 16.0.

Result:

A total of 10 studies involving 1,936 patients were included, comprising 643 cases and 1,293 controls. Meta-analysis showed that central nervous system (CNS) involvement, hypofibrinogenemia, markedly elevated ferritin levels, and leukopenia were significantly associated with MAS in sJIA, with odds ratios (95% confidence intervals) of 4.30 (2.13-8.65), 4.03 (2.87-5.65), 8.28 (5.66-12.10), and 5.98 (2.80-12.75), respectively.

Conclusion:

CNS involvement, hypofibrinogenemia, hyperferritinemia, and leukopenia are core risk factors for MAS in patients with sJIA.

Systematic Review Registration:

PROSPERO CRD420251108082.

Palabras clave:

estudio de casos y controles síndrome de activación de macrófagos metaanálisis factores de riesgo artritis idiopática juvenil sistémica

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