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Autoanticuerpos anti-interferón-γ y ensayos indeterminados de QuantiFERON®-TB Gold Plus

Serena Lee¹, Annalie J Harris¹, Christa S Zerbe¹

¹Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, Maryland, USA.

Open forum infectious diseases

|December 22, 2025

Abstract:

Among 852 samples sent for QuantiFERON^®-TB Gold Plus Assay (QFN) analysis, between 6% and 11% had IFNγ binding activity, but only 1.2% of indeterminate samples had IFNγ blocking activity. No TB negative samples had blocking activity to IFNγ. Indeterminate QFN results may indicate the presence of blocking anti-IFNγ autoantibodies.

Palabras clave:

QuantiFERON-TB Gold Plus autoanticuerpos anticitoquinas IGRA indeterminada

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