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Rapid Development of Cell State Identification Circuits with Poly-Transfection
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Ajuste de Instrucciones Multimodales de Contexto Celular para la Generación Condicional de Secuencias Regulatorias de
Junhao Liu1, Pengpeng Zhang1, Siwei Xu1
1University of California, Irvine.
Proceedings. International Conference on Image Processing
|December 22, 2025
Resumen
El diseño de potenciadores de biología sintética es un desafío. Leonine, un nuevo marco, utiliza modelos de lenguaje grandes (LLM) y datos celulares para el diseño de potenciadores conscientes del contexto, mejorando el reclutamiento y la función del factor de transcripción.
Sus antecedentes:
- El diseño de secuencias de ADN regulatorias efectivas, como los potenciadores, es crucial para la biología sintética.
- Los métodos actuales tienen dificultades con el reclutamiento de factores de transcripción (TF) específicos de tipo celular, lo que lleva a diseños de potenciadores subóptimos.
Conclusiones:
- Leonine establece un nuevo paradigma para el diseño de secuencias de ADN conscientes del contexto.
- Avanza en el campo de la biología sintética al permitir un control preciso de la regulación génica.
- Proporciona una herramienta poderosa para optimizar la función de los potenciadores en contextos celulares específicos.
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