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Videos de Conceptos Relacionados

Indirect Motor Pathways01:22

Indirect Motor Pathways

3.0K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
3.0K
Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

3.7K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
3.7K
Motor Unit Stimulation01:20

Motor Unit Stimulation

3.5K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
3.5K
Direct Motor Pathways01:11

Direct Motor Pathways

4.1K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
4.1K
Hierarchy of Motor Control01:18

Hierarchy of Motor Control

5.8K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
5.8K
Brainstem01:19

Brainstem

5.5K
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
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Psychedelics relax predictive processing in the post-acute period by remodeling cortico-cortical feedback circuits.

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Computational optimization of two-photon holographic stimulation sites<i>in vivo</i>.

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Global context rapidly shapes sensory responses in V1.

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Shared striatal neurons exhibit context-specific dynamics for internally and externally driven actions.

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Fast photostimulus optimization for holographic control of neural ensemble activity <i>in vivo</i>.

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Video Experimental Relacionado

Updated: Jan 8, 2026

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
07:52

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

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Los conjuntos estriatales especifican y controlan las acciones granulares de las extremidades anteriores

Ines Rodrigues-Vaz1,2,3,4, Vivek R Athalye1,3,4, Darcy S Peterka1,4,5

  • 1Zuckerman Mind Brain Behavior Institute, Departments of Neuroscience and Neurology; Columbia University; New York, NY, 10027; USA.

bioRxiv : the preprint server for biology
|December 22, 2025
PubMed
Resumen

Los investigadores descubrieron que grupos específicos de células cerebrales en el estriado controlan movimientos precisos. Este descubrimiento ofrece información sobre cómo la disfunción estriatal causa trastornos del movimiento específicos.

Palabras clave:
estriadoneuronas de espinosas medianascontrol motorneurocienciamovimientoaccionesenseñanzaaprendizajetrastornos del movimientoenfermedad de Huntingtondistonía

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The Vermicelli and Capellini Handling Tests: Simple quantitative measures of dexterous forepaw function in rats and mice
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The Vermicelli and Capellini Handling Tests: Simple quantitative measures of dexterous forepaw function in rats and mice

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Design and Use of an Apparatus for Presenting Graspable Objects in 3D Workspace
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Design and Use of an Apparatus for Presenting Graspable Objects in 3D Workspace

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Last Updated: Jan 8, 2026

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Área de la Ciencia:

  • Neurociencia; Control Motor; Neurociencia Computacional

Sus antecedentes:

  • El estriado es vital para el control y el aprendizaje del movimiento, y su disfunción está relacionada con trastornos del movimiento.; Tradicionalmente, se pensaba que la actividad estriatal vigorizaba ampliamente el movimiento, pero la evidencia reciente sugiere que codifica acciones específicas.; La granularidad y el papel causal de la actividad estriatal en el control de movimientos específicos en curso siguen sin estar claros.

Objetivo del estudio:

  • Investigar la especificidad y el papel causal de la actividad de las neuronas de espinosas medianas (MSN) estriatales en el control de acciones motoras finas.; Determinar si la actividad estriatal codifica movimientos distintos a nivel granular.; Explorar la función de las D1-MSN y las D2-MSN en el control de la acción.

Principales métodos:

  • Los ratones realizaron una tarea que implicaba dos acciones distintas de las extremidades anteriores (empujar/tirar) en un joystick.; Se utilizó microscopía de dos fotones para obtener imágenes de la actividad de las MSN del estriado dorsolateral durante la preparación y ejecución de la acción.; Se desarrolló un sistema de optogenética holográfica de circuito cerrado para estimular conjuntos neuronales específicos de la acción.

Principales resultados:

  • La actividad estriatal codificó la preparación y ejecución de acciones específicas, independientemente del refuerzo.; Tanto las poblaciones de D1-MSN como las de D2-MSN codificaron la identidad de la acción por igual.; La estimulación de conjuntos de MSN específicos de la acción mejoró causalmente las acciones en curso congruentes con el conjunto estimulado.

Conclusiones:

  • Conjuntos específicos de D1- y D2-MSN controlan causalmente acciones específicas en curso con alta granularidad.; Este hallazgo proporciona un marco mecanicista para comprender los déficits motores en la disfunción estriatal.; Los resultados resaltan el papel preciso del estriado en el control motor fino y la selección de acciones.