Search research articles

ACERCA DE JoVE

Visión General Liderazgo Blog Centro de Ayuda JoVE

AUTORES

Proceso de Publicación Consejo Editorial Alcance y Políticas Revisión por Pares Preguntas Frecuentes Enviar

BIBLIOTECARIOS

Testimonios Suscripciones Acceso Recursos Consejo Asesor de Bibliotecas Preguntas Frecuentes

INVESTIGACIÓN

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archivo

EDUCACIÓN

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Centro de Recursos para Profesores Sitio de Profesores

Términos y Condiciones de Uso

Política de Privacidad

Videos de Conceptos Relacionados

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por

Same author

Skeletonization of neuronal processes using Discrete Morse techniques from computational topology.

Research square·2025

Same author

Neuronal diversity and stereotypy at multiple scales through whole brain morphometry.

Nature communications·2024

Same author

The molecular cytoarchitecture of the adult mouse brain.

Nature·2023

Same author

A technology platform for standardized cryoprotection and freezing of large-volume brain tissues for high-resolution histology.

Frontiers in neuroanatomy·2023

Same author

Role of electron and hole doping in the NdNi<sub>1-</sub>V<sub></sub>O<sub>3</sub> nanostructure.

Physical chemistry chemical physics : PCCP·2023

Same author

Full-Spectrum Neuronal Diversity and Stereotypy through Whole Brain Morphometry.

Research square·2023

Search research articles

Video Experimental Relacionado

Updated: Jan 8, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Mieloma Múltiple: Una Enfermedad en Continua Evolución

¹Hematology Clinical Trial, Flinders Cancer Innovation Centre, Bedford Park, South Australia.

Critical reviews in eukaryotic gene expression

|December 22, 2025

Resumen

La investigación traslacional une los descubrimientos de la ciencia básica con las aplicaciones clínicas. Para el mieloma múltiple, este enfoque mejora el diagnóstico, el pronóstico y la supervivencia del paciente a través de tecnologías avanzadas y tratamientos en evolución.

Palabras clave:

Investigación traslacional Mieloma múltiple Oncología Medicina clínica Pronóstico

Más Videos Relacionados

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

Videos de Experimentos Relacionados

Last Updated: Jan 8, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

Área de la Ciencia:

Oncología
Medicina Traslacional
Investigación Clínica

Sus antecedentes:

La investigación básica genera conocimiento aplicable a entornos clínicos.
La investigación traslacional integra hallazgos de laboratorio en el cuidado del paciente.
El mieloma múltiple es una neoplasia hematológica incurable.

Objetivo del estudio:

Ilustrar cómo la investigación básica y la tecnología avanzan en el cuidado del mieloma múltiple.
Destacar las mejoras en el diagnóstico, la estadificación de la enfermedad y el pronóstico.
Demostrar el impacto de la investigación traslacional en los resultados de los pacientes.

Principales métodos:

Revisión de la investigación traslacional actual en mieloma múltiple.
Aplicación de tecnologías de vanguardia en diagnóstico y pronóstico.
Análisis de estrategias de tratamiento en evolución.

Principales resultados:

Mejoras significativas en el diagnóstico y la gradación de la enfermedad.
Precisión pronóstica mejorada que conduce a un mejor manejo del paciente.
Supervivencia libre de progresión prolongada para pacientes con mieloma múltiple.

Conclusiones:

La investigación traslacional es crucial para avanzar en la atención oncológica.
La evolución continua de los tratamientos ofrece esperanza para enfermedades incurables como el mieloma múltiple.
La integración de la ciencia básica y la tecnología beneficia significativamente la supervivencia y la calidad de vida del paciente.