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Los descubrimientos innovadores para prosperar con el trastorno bipolar (TB²) - protocolo de cohorte longitudinal de

Emily G Baxi¹, Megan Shanahan², Daniel L Pham¹

¹Breakthrough Discoveries for Thriving With Bipolar Disorder, Milken Institute Science Philanthropy Accelerator for Research and Collaboration, Washington, DC, USA.

International journal of bipolar disorders

|December 22, 2025

Resumen

Este estudio establece la Red Integrada para rastrear la progresión del trastorno bipolar (TB) y los factores biológicos. Su objetivo es mejorar el diagnóstico y desarrollar tratamientos personalizados para mejorar la calidad de vida de las personas con TB.

Área de la Ciencia:

Neurociencia
Psiquiatría
Genética

Sus antecedentes:

El trastorno bipolar (TB) es una condición de salud mental compleja y heterogénea.
El diagnóstico tardío y las opciones de tratamiento limitadas impactan significativamente los resultados de los pacientes.
Comprender las trayectorias de la enfermedad y los impulsores biológicos es crucial para avanzar en la atención del TB.

Objetivo del estudio:

Establecer la Red Integrada, un estudio longitudinal prospectivo a gran escala para el fenotipado profundo de personas con trastorno bipolar.
Definir las trayectorias de la enfermedad e identificar los impulsores biológicos del trastorno bipolar.
Facilitar el desarrollo de estrategias de tratamiento basadas en la precisión para el trastorno bipolar.

Principales métodos:

Fenotipado profundo longitudinal de una cohorte diversa con trastorno bipolar.
Recolección y análisis de muestras biológicas que incluyen sangre entera, suero, plasma y PBMCs.
Establecimiento del estudio longitudinal prospectivo más grande en el trastorno bipolar.

Principales resultados:

La Red Integrada está diseñada para ser el estudio longitudinal prospectivo más completo en el trastorno bipolar hasta la fecha.
Este estudio permitirá la caracterización detallada de la progresión de la enfermedad y los fundamentos biológicos.
Los datos generados apoyarán la identificación de nuevas dianas terapéuticas.

Conclusiones:

La Red Integrada está preparada para avanzar significativamente en la comprensión y el tratamiento del trastorno bipolar.
Los hallazgos contribuirán a los enfoques de medicina personalizada para el trastorno bipolar.
El estudio tiene como objetivo optimizar la calidad de vida de las personas que viven con trastorno bipolar.

Palabras clave:

Muestras biológicas y tratamientos basados en la precisión Trastorno bipolar Fenotipado profundo Estudio de cohorte longitudinal

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