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TELO2 media la carcinogénesis mamaria inducida por parabenos: un análisis integral de redes

Jing Ren^1,2,3,4, Xiaofen Li^1,2,3,4, Bin Dong^1,2,3,4

¹School of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, No. 121 University Street, Yuci District, Jinzhong, 030619, China.

BMC pharmacology & toxicology

|December 23, 2025

Resumen

Los parabenos (PBs) pueden aumentar el riesgo de cáncer de mama al dirigirse al gen TELO2. Este estudio revela PBs

Área de la Ciencia:

Ciencias de la Salud Ambiental; Genómica y Biología Molecular; Investigación sobre el Cáncer

Sus antecedentes:

Los parabenos (PBs) se asocian con un mayor riesgo de cáncer de mama, pero los mecanismos moleculares no están claros.
Comprender los efectos de los PB es crucial para la salud ambiental y las estrategias de prevención del cáncer.

Objetivo del estudio:

Elucidar las dianas moleculares y los mecanismos de los parabenos en el cáncer de mama.
Integrar la toxicología de redes, la bioinformática y la aleatorización mendeliana para un análisis integral.

Principales métodos:

Toxicología de redes para identificar posibles dianas de PB.
Bioinformática y aleatorización mendeliana (MR) para analizar asociaciones genéticas.
Acoplamiento molecular para confirmar las interacciones PB-proteína.

Principales resultados:

Identificó 172 dianas de PB relacionadas con el cáncer de mama, afectando las vías PI3K-Akt y del ciclo celular.
TELO2 identificado como factor de riesgo de cáncer de mama; expresión elevada en tumores.
Confirmó la unión de PB a TELO2; identificó redes reguladoras de miRNA y lncRNA.

Conclusiones:

Los parabenos pueden promover el cáncer de mama al dirigirse al gen TELO2 y las redes asociadas.
Los hallazgos avanzan la comprensión de los impulsores ambientales del cáncer de mama.
Sugiere potencial para intervenciones dirigidas contra exposiciones ambientales.

Palabras clave:

Bioinformática Cáncer de mama Aleatorización mendeliana Toxicología de redes Parabenos

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