Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Neurulation01:30

Neurulation

45.0K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
45.0K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.5K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.5K
Nucleoid01:24

Nucleoid

754
The nucleoid represents a structurally and functionally distinct region within prokaryotic cells, where the cell's DNA and associated proteins are housed. Unlike eukaryotic cells, prokaryotes lack a membrane-bound nucleus, and the nucleoid facilitates the organization and accessibility of the genetic material within this constraint. The DNA in most bacteria and archaea exists as a single, circular, double-stranded molecule that is highly compacted through supercoiling and interactions with...
754
Eukaryotic Compartmentalizations01:46

Eukaryotic Compartmentalizations

171.7K
One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...
171.7K
Eukaryotic Compartmentalization01:37

Eukaryotic Compartmentalization

17.4K
One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal...
17.4K
Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

8.9K
Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
8.9K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Correction: How pain intensity and mental disorders shape chronic pain sick leave and quality of life in the general Spanish population.

Scientific reports·2026
Same author

Clinical Spectrum of Anti-SEZ6L2 Syndrome: A Case Report With Brain Volumetry and Systematic Literature Review.

Neurology(R) neuroimmunology & neuroinflammation·2026
Same author

Hyperbaric oxygen therapy improves clinical symptoms and functional capacity and modulates thalamic connectivity in ME/CFS: a prospective cohort study.

Journal of translational medicine·2026
Same author

Temporal dynamics of neuroplasticity and neurodegeneration in the central auditory system following noise-induced hearing loss: a multimodal imaging and histological study.

Acta neuropathologica communications·2026
Same author

The functional impact of LGI1 autoantibodies on human CA3 pyramidal neurons.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Long-term memory reorganization of navigational episodes.

Nature human behaviour·2026
Same journal

Correction to "Nanoparticles (NPs)-Meditated LncRNA AFAP1-AS1 Silencing to Block Wnt/β-Catenin Signaling Pathway for Synergistic Reversal of Radioresistance and Effective Cancer Radiotherapy".

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Femtosecond-Laser Nanocavitation Regenerates SERS-Active Plasmonic Nanogaps for Longitudinal Molecular Sensing at Biointerfaces.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Correction to "Bioinspired Polyacrylic Acid-Based Dressing: Wet Adhesive, Self-Healing, and Multi-Biofunctional Coacervate Hydrogel Accelerates Wound Healing".

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Non-Line-of-Sight Passive Ammonia Sensor Loaded With MXene/In<sub>2</sub>O<sub>3</sub> Composites for Agricultural Products Quality Deterioration Detection.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Cerium Nanoparticle-Mediated Inhibition of the NSUN2/m<sup>5</sup>C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Biomimetic Nanoplatform for Dual Target Nano-Metabolic Therapy in Diabetes-Associated Biofilm Infections.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jan 8, 2026

Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77
12:30

Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77

Published on: August 17, 2015

7.8K

Nurr1 orquesta el desarrollo y la funcionalidad del claustro

Kuo Yan1, Andrew G Newman1, Pauline Lange1

  • 1Institute of Cell Biology and Neurobiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 23, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Nurr1 es un factor de transcripción clave esencial para el desarrollo y la función del claustro, una región del cerebro implicada en la cognición. Su ausencia provoca anomalías estructurales y déficits conductuales en ratones.

Palabras clave:
Nurr1 (Nr4a2)comportamientos dependientes del claustromorfogénesis del claustroconectividad funcionaltranscriptoma de célula única

Más Videos Relacionados

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
09:02

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Published on: December 10, 2015

7.7K
Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development
04:20

Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development

Published on: June 9, 2021

3.0K

Videos de Experimentos Relacionados

Last Updated: Jan 8, 2026

Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77
12:30

Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77

Published on: August 17, 2015

7.8K
Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
09:02

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Published on: December 10, 2015

7.7K
Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development
04:20

Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development

Published on: June 9, 2021

3.0K

Área de la Ciencia:

  • Neurociencia
  • Biología del Desarrollo
  • Biología Molecular

Sus antecedentes:

  • El claustro, una estructura del prosencéfalo, está ampliamente interconectado y es crucial para funciones cognitivas como la conciencia.
  • Los mecanismos moleculares que rigen el desarrollo del claustro y el control conductual siguen siendo en gran medida desconocidos.

Objetivo del estudio:

  • Elucidar los mecanismos moleculares subyacentes al desarrollo del claustro y su papel en el control conductual.
  • Identificar los factores de transcripción clave implicados en la morfogénesis del claustro y la especificación del destino celular.

Principales métodos:

  • Se investigó el papel de Nurr1 (Nr4a2) en modelos de ratón con deficiencia de Nurr1.
  • Se utilizó transcriptómica de célula única para analizar los cambios en la expresión génica.
  • Se examinó la conectividad estructural y funcional del claustro.
  • Se evaluaron los fenotipos conductuales en ratones deficientes en Nurr1.

Principales resultados:

  • Nurr1 se identifica como un factor de transcripción crítico para el desarrollo del claustro, incluida la morfogénesis, el destino celular y la conectividad.
  • La deficiencia de Nurr1 causa una migración aberrante de las células del claustro, alterando la estructura del claustro y activando programas genéticos ectópicos.
  • Se observaron alteraciones en la conectividad del claustro y comportamientos desregulados en ratones deficientes en Nurr1.
  • Nurr1 suprime la señalización Gαs-PKA para regular el posicionamiento neuronal y el destino celular.

Conclusiones:

  • Nurr1 desempeña un papel fundamental en la orquestación del desarrollo y la función del claustro.
  • La alteración de la función de Nurr1 conduce a anomalías cerebrales estructurales y déficits conductuales.
  • La regulación de la señalización Gαs-PKA por parte de Nurr1 es un mecanismo clave para controlar el desarrollo de las neuronas del claustro.