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Updated: Jan 8, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Aceleración de la generación de evidencia a la implementación: Establecimiento del consorcio Leading Awareness to
Laney K Jones1, Ty J Gluckman2, Ankeet S Bhatt3,4
1Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA, USA.
Abstract:
Recent scientific advancements have led to the availability of innovative therapies to reduce the risk of cardiometabolic events, offering new tools to address the world's leading cause of mortality. The length of time from evidence generation to implementation in healthcare settings remains far from optimal, resulting in missed opportunities to improve morbidity and mortality and unrealized population-level benefit. Established in 2023, the Leading Awareness to Action through Implementation of Cardiometabolic Efforts (LATTICE™) consortium's mission is to unite partners dedicated to improving cardiometabolic health by creating an inclusive platform for sharing evidence-based tools, methodologies, and strategies to address gaps in care at scale. The LATTICE consortium aims to accomplish this by 1) exploring novel strategies for translating evidence-based advancements across diverse clinical practice settings and 2) disseminating successful strategies through a unique collaboration among clinicians, healthcare systems, payors, patients, patient advocacy groups, and life science companies. The LATTICE consortium is prioritizing projects that rigorously test strategies grounded in implementation science and hold significant promise for uptake at scale. Success of the LATTICE consortium will be assessed through improved awareness, access, and implementation of effective, scalable, and sustainable health care strategies that address cardiometabolic gaps in care.
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