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Coentrega de VRK1 para mitigar la aglomeración de ADN por BAF en la transfección de TFAMoplex

Christina Greitens1, Philip Maurer1, Selen Balkan1

  • 1Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.

Materials today. Bio
|December 23, 2025
PubMed
Resumen

Desarrollamos un nuevo sistema de entrega de genes, SpyTFAMoplex, que previene la aglomeración de ADN en el citoplasma. Sin embargo, este sistema redujo inesperadamente la eficiencia de transfección génica, lo que sugiere una posible interferencia con el ADN

Palabras clave:
fosforilación de BAFimagen intracelularnanopartículasentrega de genes no viraltransfección basada en proteínasVRK1

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