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Efecto de Enterococcus faecalis en la variación de fase de Clostridioides difficile

Ashley S Weiss1,2, Jilarie A Santos-Santiago3, Orlaith Keenan1,2

  • 1Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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|December 23, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Enterococcus faecalis influye en la variación de fase de Clostridioides difficile, alterando la heterogeneidad de su población. Esta interacción impacta los fenotipos de C. difficile, destacando el papel de los entornos polimicrobianos en la adaptación y persistencia del patógeno.

Palabras clave:
morfología de coloniasvariación de faseinteracciones polimicrobianasmotilidad superficial

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Área de la Ciencia:

  • Microbiología
  • Interacciones patógeno-huésped
  • Ecología microbiana

Sus antecedentes:

  • Patógenos entéricos como Clostridioides difficile utilizan la variación de fase para la adaptación.
  • La influencia de la microbiota intestinal en la heterogeneidad del patógeno está poco estudiada.
  • Enterococcus faecalis coinfecta el intestino con C. difficile.

Objetivo del estudio:

  • Investigar cómo Enterococcus faecalis afecta la variación de fase de Clostridioides difficile.
  • Explorar el impacto de las interacciones polimicrobianas en la heterogeneidad de la población de C. difficile.

Principales métodos:

  • Cultivo conjunto de E. faecalis y C. difficile en medios sólidos.
  • Observación de cambios en la morfología de colonias y características celulares de C. difficile.
  • Análisis del papel del sistema de transducción de señales CmrRST en los cambios fenotípicos.

Principales resultados:

  • E. faecalis alteró significativamente los fenotipos de C. difficile asociados con la variación de fase CmrRST.
  • E. faecalis promovió un cambio al estado 'cmr-ON' en C. difficile, causando encadenamiento celular y colonias rugosas.
  • Este efecto fue específico de E. faecalis, y otras bacterias probadas no mostraron un impacto similar.

Conclusiones:

  • Los entornos polimicrobianos, específicamente la presencia de E. faecalis, influyen críticamente en la heterogeneidad de la población de C. difficile.
  • La ecología microbiana y las interacciones juegan un papel complejo en la configuración de la variación fenotípica del patógeno.
  • La comprensión de estas interacciones puede revelar nuevas dianas terapéuticas para las infecciones por C. difficile.