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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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Consorcio de Imagenología de Alzheimer

Stuart William Mitchell1,2, Tevy Chan1,2,3, Lydia Trudel1,2,3,4,5,6,7

  • 1Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montréal, QC, Canada.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La extensión espacial de la tauopatía (SEOT) predice mejor el deterioro cognitivo en la enfermedad de Alzheimer que la carga de tau (SUVR). La SEOT puede ser un marcador más sensible de la progresión de la enfermedad neurodegenerativa.

Palabras clave:
tauopatíaSUVRdeterioro cognitivoenfermedad de Alzheimerbiomarcadorneurodegeneración

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Área de la Ciencia:

  • Neuroimagen; Investigación de la Enfermedad de Alzheimer; Neurociencia Cognitiva

Sus antecedentes:

  • La resiliencia cerebral y cognitiva (BR, CR) son clave para mantener la función a pesar de la patología tau de la enfermedad de Alzheimer (EA).; La patología tau se puede medir por extensión espacial (SEOT) o carga (SUVR).; Comprender los factores que influyen en BR y CR es crucial para el manejo de la EA.

Objetivo del estudio:

  • Comparar el SEOT y el SUVR en su asociación con BR y CR.; Replicar hallazgos previos utilizando imágenes PET con MK-6240.; Evaluar factores demográficos, genéticos y de imagen relacionados con BR y CR.

Principales métodos:

  • 126 participantes positivos para beta-amiloide de la cohorte TRIAD se sometieron a tau-PET ([18F]MK6240) y evaluaciones cognitivas (MMSE).; El SEOT se cuantificó como la proporción de vóxeles con deposición anormal de tau en relación con controles jóvenes.; Los participantes incluyeron individuos con deterioro cognitivo leve (MCI) o EA.

Principales resultados:

  • El SUVR MK de la corteza total más alto se correlacionó con puntuaciones más bajas de la MMSE, lo que indica que la patología tau está relacionada con el deterioro cognitivo.; Los pacientes con MCI mostraron puntuaciones más altas de la MMSE a pesar de cierta acumulación de tau en comparación con los pacientes con EA.; El SEOT de la corteza total demostró una correlación negativa más fuerte con la MMSE que el SUVR, lo que sugiere que el SEOT es más sensible al deterioro cognitivo.

Conclusiones:

  • El SEOT de la corteza total es un marcador más sensible del deterioro cognitivo en la EA y el MCI que el SUVR de MK-6240 de la corteza total.; El SEOT muestra una asociación más fuerte con la progresión del deterioro cognitivo.; Se necesita más investigación para validar el SEOT como biomarcador de condiciones neurodegenerativas.