Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

251
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
251
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

212
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
212
Brain Imaging01:14

Brain Imaging

629
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
629
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

460
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
460
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

758
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
758

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Plasma proteomic profiles of Alzheimer's disease and neurodegeneration in African cohorts.

Nature communications·2026
Same author

[<sup>18</sup>F]RO948 Tau PET in early and late onset Alzheimer's disease: associations with plasma p-tau 217, atrophy and cognition.

European journal of nuclear medicine and molecular imaging·2026
Same author

Aβ- and tau-associated neuroinflammatory signatures in Alzheimer's disease.

Alzheimer's & dementia (New York, N. Y.)·2026
Same author

Association between automated brain volumetry and visual classification of hippocampal atrophy in MRI.

Neuroimage. Reports·2026
Same author

Tau extent outperforms tau load as a predictor of neurodegeneration in Alzheimer's disease.

Molecular neurodegeneration·2026
Same author

Comparison of [18F]flortaucipir and [18F]MK6240 for the detection of tau pathology in Alzheimer's disease (HEAD): a multicentre, prospective, cross-sectional, within-participant study.

Lancet (London, England)·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Correlates and predictors of self-efficacy among dementia caregivers: D-CARE findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

What should convince a clinician of disease modification in Alzheimer's disease clinical trials?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Primary cilia-extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751

Consorcio de Imagenología de Alzheimer

Luiza Santos Machado1, Guilherme Povala2, Ilaria Pola3

  • 1Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, VG, Sweden.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Se identifican nuevos biomarcadores astrocíticos, GPC5, LRIG1 y NCAN, en el líquido cefalorraquídeo (LCR) de la enfermedad de Alzheimer (EA). Estos biomarcadores se correlacionan con la patología amiloide y el estado cognitivo, ofreciendo potencial para mejorar el diagnóstico de la EA.

Palabras clave:
Enfermedad de Alzheimerbiomarcadores astrocíticoslíquido cefalorraquídeoneuroimagenologíapatología amiloideestado cognitivoGPC5LRIG1NCAN

Más Videos Relacionados

Visualization of Amyloid &#946; Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

Videos de Experimentos Relacionados

Last Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751
Visualization of Amyloid &#946; Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

Área de la Ciencia:

  • Neurociencia
  • Descubrimiento de biomarcadores
  • Investigación de la enfermedad de Alzheimer

Sus antecedentes:

  • Los astrocitos desempeñan un papel crítico en la fisiopatología de la enfermedad de Alzheimer (EA).
  • La proteína ácida fibrilar glial (GFAP) es un biomarcador conocido de la reactividad astrocítica en la EA, pero no captura completamente la dinámica de la enfermedad.
  • Existe la necesidad de nuevos biomarcadores astrocíticos en el líquido cefalorraquídeo (LCR) para comprender mejor los cambios patológicos relacionados con la EA.

Objetivo del estudio:

  • Identificar nuevos biomarcadores astrocíticos específicos en LCR para la enfermedad de Alzheimer.
  • Investigar la asociación de estos biomarcadores con el estado cognitivo y la patología amiloide.

Principales métodos:

  • Análisis de datos proteómicos de LCR de 728 individuos de la cohorte de Iniciativa de Neuroimagen de la Enfermedad de Alzheimer (ADNI).
  • Examen de los niveles de proteínas en LCR (incluyendo GFAP, GPC5, LRIG1, NCAN) en grupos de individuos cognitivamente no afectados, con deterioro cognitivo leve y con EA.
  • Evaluación de las asociaciones entre los niveles de proteínas en LCR y la deposición de beta-amiloide (Aβ) mediante imágenes de PET con [18F]Florbetapir.

Principales resultados:

  • Los niveles de NCAN en LCR fueron significativamente reducidos en individuos con EA en comparación con los grupos de individuos cognitivamente no afectados (CU) y con deterioro cognitivo leve (MCI).
  • Los niveles de GPC5 en LCR se elevaron en individuos con deterioro cognitivo y beta-amiloide positivo.
  • GPC5, LRIG1 y NCAN en LCR mostraron asociaciones positivas con la deposición de Aβ, y GPC5 demostró las asociaciones corticales más extendidas.

Conclusiones:

  • GPC5, LRIG1 y NCAN se identifican como nuevos biomarcadores astrocíticos en LCR que se alteran en la enfermedad de Alzheimer.
  • GPC5 presenta una fuerte asociación con la deposición de amiloide, lo que sugiere su potencial como biomarcador sensible para la EA.
  • Estos hallazgos resaltan el potencial de GPC5 como un nuevo biomarcador astrocítico para la EA, con una mayor validación planificada.