Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

251
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
251
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

212
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
212
Brain Imaging01:14

Brain Imaging

629
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
629
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

460
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
460
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

758
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
758

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Non-invasive MRI of choroid plexus vascular function.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Correspondence of large-scale functional brain network decline across aging mice and humans.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Systematic fMRI signal differences across cohorts alter lifespan connectome trajectories.

bioRxiv : the preprint server for biology·2026
Same author

Resting-state functional network segregation of the default mode network predicts valence bias across the lifespan.

Imaging neuroscience (Cambridge, Mass.)·2025
Same author

Less is More: Lower Levels of Task-Induced Hippocampal Activation Predict Better Performance on a Separate Verbal Memory Evaluation.

bioRxiv : the preprint server for biology·2025
Same author

The Dallas Lifespan Brain Study: A Comprehensive Adult Lifespan Data Set of Brain and Cognitive Aging.

Scientific data·2025
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751

Consorcio de Imágenes de Alzheimer

Roy Massett1, Ziwei Zhang1, Micaela Chan1

  • 1University of Texas at Dallas, Richardson, TX, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La enfermedad de Alzheimer (EA) muestra cambios distintos en las redes cerebrales. La fMRI en estado de reposo revela dos subtipos de desegregación de redes, que afectan diferentes funciones cognitivas y la progresión de la enfermedad.

Palabras clave:
enfermedad de Alzheimerresonancia magnética funcionalredes cerebralesneuroimagencogniciónprogresión de la enfermedad

Más Videos Relacionados

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

Videos de Experimentos Relacionados

Last Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

Área de la Ciencia:

  • Neurociencia
  • Ciencias Cognitivas
  • Imagenología Médica

Sus antecedentes:

  • La enfermedad de Alzheimer (EA) es un trastorno neurológico complejo con patología y síntomas clínicos variados.
  • La organización de las redes cerebrales está relacionada con la EA, y el aumento de la gravedad de la demencia se correlaciona con la desegregación de la red.
  • La heterogeneidad de estos cambios en la red y su impacto en los déficits cognitivos requieren una mayor investigación.

Objetivo del estudio:

  • Investigar la heterogeneidad espaciotemporal de los cambios en las redes cerebrales en la enfermedad de Alzheimer.
  • Identificar subtipos distintos de alteraciones en la organización de redes utilizando un enfoque basado en datos.
  • Correlacionar los cambios en la red con los déficits cognitivos y la progresión de la enfermedad.

Principales métodos:

  • Se utilizaron 754 escáneres de resonancia magnética funcional (fMRI) en estado de reposo de individuos con deterioro cognitivo.
  • Se construyeron redes cerebrales utilizando correlaciones de series temporales de fMRI y se asignaron nodos a sistemas funcionales.
  • Se aplicó el algoritmo SuStaIn para identificar subtipos y etapas basados en patrones de segregación de redes.

Principales resultados:

  • Se identificaron dos subtipos distintos de alteración en la segregación de redes a nivel de sistema en la enfermedad de Alzheimer.
  • Un subtipo mostró una segregación disminuida en sistemas sensoriomotores y otros.
  • el segundo mostró una segregación disminuida en sistemas de asociación.
  • Se observó una interacción significativa entre el tipo de sistema, la etapa de la enfermedad y el subtipo, lo que indica una progresión diferencial.

Conclusiones:

  • La fMRI en estado de reposo puede diferenciar patrones de desegregación de redes cerebrales en la EA, vinculados a diversos déficits cognitivos.
  • Los hallazgos ilustran la heterogeneidad de la disminución de las redes cerebrales y su relación con las trayectorias cognitivas en la EA.
  • Estas ideas son valiosas para los pronósticos de la EA y la evaluación de los resultados de los ensayos clínicos en diversas poblaciones de pacientes.