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Alzheimer's Disease: Overview

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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on ¹⁸F-AV-1451

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Consorcio de Imagenología de Alzheimer

Rufeyda Yagci¹, Tatjana Schmidt², Marcella Montagnese²

¹Istanbul Medipol University, Istanbul, Istanbul, Turkey.

Alzheimer's & dementia : the journal of the Alzheimer's Association

|December 23, 2025

Resumen

Este resumen es generado por máquina.

La imagen por tensor de difusión (DTI) revela cambios significativos en la sustancia blanca en pacientes con enfermedad de Alzheimer (EA), lo que respalda su uso en el diagnóstico clínico. Estas alteraciones microestructurales en regiones clave del cerebro resaltan las interrupciones en las funciones de memoria y ejecutivas.

Conclusiones:

Las medidas de DTI muestran potencial como herramientas de diagnóstico para la evaluación de la enfermedad de Alzheimer en la práctica clínica rutinaria.
Los cambios observados en la sustancia blanca en las estructuras y vías del sistema límbico respaldan las interrupciones en la memoria, el procesamiento ejecutivo y la comunicación interhemisférica en la EA.
Los hallazgos proporcionan una base para una mayor investigación sobre la aplicación diagnóstica de DTI para la patología de la EA.

Palabras clave:

Imagen por tensor de difusión Enfermedad de Alzheimer Sustancia blanca Diagnóstico clínico Neuroimagenología

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