Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

251
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
251
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

212
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
212
Brain Imaging01:14

Brain Imaging

629
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
629
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

460
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
460
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

758
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
758

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.

JAMA·2026
Same author

CSF and plasma tau biomarkers in the Down syndrome-Alzheimer's disease continuum.

EBioMedicine·2026
Same author

Hypertension is the most common cardiovascular risk factor in cancer patients - data from the CONNECT-POL registry.

Kardiologia polska·2026
Same author

The predictive power of neuropsychological measures in MCI: early detection of dementia conversion.

Frontiers in aging neuroscience·2026
Same author

Cerebrospinal fluid NPTX2/p-tau ratio as a biomarker for cognitive decline in neurodegenerative diseases.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Clinical Impact and Prognostic Value of Alzheimer Disease Biomarkers in the Very Old.

Neurology·2026

Video Experimental Relacionado

Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751

Consorcio de Imagenología de Alzheimer

Ganna Blazhenets1, Heather M Snyder2, Liana G Apostolova3

  • 1Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
Resumen

El marco Centiloid estandariza la imagenología de amiloide-PET. El meta-análisis reveló un punto de corte común de 19 Centiloides (CL), pero la alta heterogeneidad del estudio sugiere precaución al aplicar umbrales universales.

Palabras clave:
Centiloidamiloide-PETpunto de cortemeta-análisisheterogeneidad

Más Videos Relacionados

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

Videos de Experimentos Relacionados

Last Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

Área de la Ciencia:

  • Neuroimagen
  • Biomarcadores
  • Investigación de la Enfermedad de Alzheimer

Sus antecedentes:

  • El marco Centiloid es ampliamente adoptado para armonizar la cuantificación de amiloide-PET y facilitar la comparación de datos multicoorte.
  • Ayuda a estandarizar la interpretación de la imagenología de amiloide en entornos de investigación y clínicos.

Objetivo del estudio:

  • Evaluar la implementación global del marco Centiloid comparando las distribuciones de Centiloides y los umbrales de positividad en diversas cohortes.
  • Establecer puntos de corte estandarizados para la positividad de amiloide-PET mediante meta-análisis.

Principales métodos:

  • Se recopilaron datos de 37 cohortes disponibles públicamente (n=41.678), incluidos valores de Centiloides, datos demográficos y lecturas visuales.
  • Se utilizaron modelos de mezcla gaussianos (GMM) para determinar los picos y puntos de corte de Centiloides (media + 2DE de la gaussiana inferior) para cada cohorte.
  • Los meta-análisis de efectos aleatorios combinaron datos de las cohortes, con análisis de subgrupos que examinaron los efectos de los procesos de procesamiento, los radiotrazadores y los entornos de estudio. La correspondencia con las lecturas visuales se evaluó mediante el índice kappa de Cohen.

Principales resultados:

  • Se identificó un pico común de Centiloides en 1 CL, con heterogeneidad significativa en el segundo pico (resultado del meta-análisis: 64 CL).
  • El meta-análisis arrojó un punto de corte basado en GMM de 19 CL (IC del 95%: 16-21 CL), sin diferencias significativas entre los radiotrazadores o los entornos de estudio.
  • Un punto de corte basado en lectura visual de 24 CL (IC del 95%: 21-27 CL) mostró una fuerte correspondencia con los Centiloides (kappa=0.86), pero se observó una alta heterogeneidad intergrupos (I²>80%).

Conclusiones:

  • Los puntos de corte de Centiloides derivados del meta-análisis son consistentes con la literatura existente.
  • La heterogeneidad significativa entre los estudios resalta la necesidad de investigar los factores contribuyentes y plantea preocupaciones sobre la aplicación universal de puntos de corte comunes.