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Salud Pública
Pei Huang1, Chao Gao1, Yuyan Tan1
1Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
Resumen
Este estudio evalúa el Entrenamiento Virtual de Rehabilitación Cerebral y Corporal (BBRT) en pacientes con Parkinson con deterioro cognitivo leve (PD-MCI) y deterioro cognitivo subjetivo (PD-SCI). El ensayo de 3 años evalúa la eficacia de BBRT en la mejora de la función cognitiva y biomarcadores digitales.
Área de la Ciencia:
- Neurociencia
- Terapias Digitales
- Rehabilitación Cognitiva
Sus antecedentes:
- No existen tratamientos farmacológicos eficaces para retrasar el deterioro cognitivo leve (MCI) a demencia.
- Las intervenciones multidominio (entrenamiento cognitivo, ejercicio, dieta) son prometedoras.
- Las terapias digitales ofrecen beneficios cognitivos mejorados a través de diversos estímulos.
Objetivo del estudio:
- Investigar la eficacia del Entrenamiento Virtual de Rehabilitación Cerebral y Corporal (BBRT) en pacientes con deterioro cognitivo leve (PD-MCI) en la enfermedad de Parkinson.
- Evaluar la efectividad de BBRT en pacientes con deterioro cognitivo subjetivo (PD-SCI) en la enfermedad de Parkinson.
- Explorar intervenciones no farmacológicas para la mejora cognitiva en pacientes con EP.
Principales métodos:
- Ensayo controlado aleatorizado de 3 años y cuatro brazos con 260 participantes (130 PD-MCI, 130 PD-SCI).
- Participantes de 55 a 80 años, asignados aleatoriamente a la intervención BBRT o control (educación sanitaria).
- Grupo BBRT: ≥5 sesiones virtuales/semana, ≥15 min/sesión, realizadas de forma remota durante 36 meses.
Principales resultados:
- Resultado primario: Puntuación total de la Montreal Cognitive Assessment (MOCA).
- Resultados secundarios: Escalas neuropsicológicas, biomarcadores digitales (marcha, habla, escritura), biomarcadores sanguíneos e neuroimagen (RM).
- Evaluaciones al inicio, a los 12, 24 y 36 meses.
Conclusiones:
- Evaluar sistemáticamente la eficacia clínica de BBRT-virtual en pacientes chinos con PD-MCI y PD-SCI.
- Proporcionar información sobre los mecanismos de las intervenciones no farmacológicas para la mejora de la función cognitiva.
- Evaluar el impacto de BBRT en la función cognitiva y los biomarcadores digitales en pacientes con EP.
Palabras clave:
Salud PúblicaRehabilitación Cerebral y CorporalEnfermedad de ParkinsonDeterioro Cognitivo LeveDeterioro Cognitivo SubjetivoEnsayos Controlados AleatorizadosBiomarcadores DigitalesNeurocienciaTerapias DigitalesRehabilitación CognitivaMás Videos Relacionados
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