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Salud Pública

Andrea Z LaCroix1, Bowei Zhang1, Linda K McEvoy2

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PubMed
Resumen
Este resumen es generado por máquina.

Las medidas de aceleración de la edad epigenética predicen la supervivencia hasta los 90 años en mujeres, pero no distinguen entre aquellas con o sin cognición preservada. Se necesita un mayor desarrollo para la predicción del estado cognitivo.

Palabras clave:
Salud PúblicaAceleración de la edad epigenéticaLongevidadEstado cognitivoEnvejecimiento

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Área de la Ciencia:

  • Epigenética
  • Gerontología
  • Ciencia Cognitiva

Sus antecedentes:

  • Los estimadores de aceleración de la edad epigenética (EAA) predicen la mortalidad pero no fueron entrenados en longevidad o cognición preservada.
  • La capacidad de las medidas de EAA para predecir la larga supervivencia con cognición intacta sigue siendo en gran medida desconocida.

Objetivo del estudio:

  • Investigar si las medidas de EAA predicen la supervivencia a los 90 años con cognición preservada.
  • Comparar el poder predictivo de las medidas de EAA para la supervivencia con o sin deterioro cognitivo.

Principales métodos:

  • Análisis de 5293 mujeres de la cohorte WHIMS, nacidas antes del 28 de febrero de 1934.
  • Se examinaron 14 estimadores de EAA en relación con la supervivencia a los 90 años con cognición preservada, sin cognición preservada o muerte antes de los 90 años.
  • Se utilizó regresión logística multinomial, ajustando por múltiples covariables, incluyendo edad, educación, raza y factores de salud.

Principales resultados:

  • Todos los estimadores de edad acelerada se asociaron con la supervivencia a los 90 años con deterioro cognitivo.
  • Las asociaciones fueron en la misma dirección y magnitud similar para la supervivencia a los 90 años sin deterioro cognitivo.
  • Las versiones de componentes principales (PC) de los estimadores mostraron asociaciones ligeramente más fuertes para ambos resultados de longevidad.

Conclusiones:

  • Las medidas de EAA predicen consistentemente la supervivencia a los 90 años en mujeres mayores.
  • Las medidas de EAA no predicen de manera diferencial la supervivencia con o sin cognición intacta.
  • Los hallazgos apoyan el desarrollo de medidas de EAA específicamente entrenadas en el estado cognitivo preservado en la edad avanzada.