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Salud Pública

Julie Chandler1, Zachary Sheff1, Nalin Payakachat1

  • 1Eli Lilly & Company, Indianapolis, IN, USA.

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|December 23, 2025
PubMed
Resumen
Este resumen es generado por máquina.

A medida que la enfermedad de Alzheimer (EA) progresa, el gasto de Medicare aumenta significativamente. La identificación e intervención tempranas en la EA preclínica son cruciales para posibles ahorros de costos y mejores resultados para los pacientes.

Palabras clave:
enfermedad de Alzheimercostos de atención médicautilización de recursosfase preclínicaahorros de costos

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Área de la Ciencia:

  • Gerontología
  • Neurociencia
  • Economía de la Salud

Sus antecedentes:

  • La progresión de la enfermedad de Alzheimer (EA) preclínica y la utilización de recursos de atención médica (HRU) siguen siendo poco comprendidas.
  • La identificación temprana de indicadores de progresión clínica en etapas asintomáticas de la EA es crítica.

Objetivo del estudio:

  • Caracterizar la progresión de la EA y la utilización de recursos en individuos cognitivamente sanos con amiloide elevado.
  • Evaluar la asociación entre los marcadores de progresión de la EA y la utilización de recursos y los costos de atención médica.

Principales métodos:

  • Se vincularon los datos de reclamaciones de Medicare con los resultados del estudio Anti-Amyloid Treatment in Asymptomatic AD (A4) para 246 participantes.
  • Se definió la progresión de la EA utilizando la Escala de Evaluación Clínica de Demencia-Puntuación Global (CDR-GS) y los datos de Medicare (diagnóstico de deterioro cognitivo, diagnóstico de EA, Índice de Fragilidad JEN [JFI] ≥ 6).
  • Se analizaron las asociaciones entre la progresión de la EA y los diagnósticos, encuentros y pagos utilizando regresión logística y regresión lineal.

Principales resultados:

  • El 38% de los participantes mostraron progresión de CDR-GS; el 46% tuvo un diagnóstico de deterioro cognitivo, el 24% un diagnóstico de EA y el 30% un JFI ≥ 6.
  • La progresión de la EA se asoció con un aumento de los diagnósticos de trastornos del ánimo y de ansiedad, caídas y una mayor utilización de hospitalizaciones.

Conclusiones:

  • El gasto de Medicare aumenta a medida que la enfermedad de Alzheimer progresa de las etapas preclínicas a las sintomáticas.
  • Se necesita más investigación para explorar los ahorros de costos asociados con el retraso de la progresión a la EA sintomática.