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Salud Pública

Monica K Crane1, Lee Watson2, Amanda Blackwood3

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El análisis de las redes sociales revela que lecanemab puede ralentizar la progresión del Alzheimer, mejorando el tiempo de calidad del paciente. Sin embargo, los efectos secundarios reportados como ARIA, hemorragias cerebrales e hinchazón influyen en las decisiones de tratamiento.

Palabras clave:
LecanemabEnfermedad de AlzheimerRedes socialesEfectos secundariosARIASalud públicaEstudios retrospectivosCuidadoresPacientes

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Área de la Ciencia:

  • Neurología; Gerontología; Farmacología

Sus antecedentes:

  • Existen pocas perspectivas de pacientes y cuidadores en el mundo real para lecanemab en la Enfermedad de Alzheimer (EA).; La comprensión de las perspectivas de los pacientes es crucial para evaluar la efectividad y la experiencia del tratamiento.; Las redes sociales ofrecen una plataforma para discusiones francas de pacientes y cuidadores.

Objetivo del estudio:

  • Investigar las experiencias clínicas en el mundo real con lecanemab desde la perspectiva de los pacientes y cuidadores.; Analizar datos de redes sociales para identificar temas relacionados con el tratamiento con lecanemab en la Enfermedad de Alzheimer.; Identificar los resultados y preocupaciones reportados por los pacientes asociados con la terapia con lecanemab.

Principales métodos:

  • Análisis retrospectivo de 468 publicaciones en redes sociales relacionadas con lecanemab (EE. UU., enero de 2023 - octubre de 2024).; Datos recopilados a través de Brandwatch, Sprinklr y Buzzsumo, centrándose en lenguaje en primera persona o familiar.; Revisión sistemática cualitativa de 78 publicaciones que detallan experiencias clínicas; análisis cuantitativo de frecuencia de palabras clave.

Principales resultados:

  • Los cuidadores informaron que lecanemab ralentizó la progresión de la enfermedad, permitiendo más tiempo de calidad (N=13).; Las experiencias positivas incluyeron mejoras cognitivas y funcionales (N=16), como mejores actividades diarias.; Mención frecuente de efectos secundarios (N=30), incluyendo ARIA (N=13), hemorragias cerebrales (n=6) e hinchazón (N=5), que impactaron la percepción del tratamiento.

Conclusiones:

  • Se percibe que lecanemab ralentiza la progresión del Alzheimer y extiende el tiempo de calidad con los seres queridos.; Los efectos secundarios reportados son un factor importante que influye en la decisión de iniciar o continuar el tratamiento con lecanemab.; La escucha en redes sociales proporciona información valiosa sobre las consideraciones de atención al paciente y las posibles mejoras.