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Consorcio de Imagenología de Alzheimer

Nicolás Lamanna-Rama1,2, Marta Casquero-Veiga2,3, Carlos Ceron2

  • 1Consejo Superior de Investigaciones Científicas - Centro Internacional de Neurociencia Cajal (CSIC - CINC), Alcalá de Henares, Madrid, Spain.

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Resumen
Este resumen es generado por máquina.

La enfermedad de Alzheimer (EA) implica un aumento de fibrina en el cerebro, lo que contribuye a la neurodegeneración. El proyecto BioClotAD desarrolló sondas de unión a fibrina para la detección temprana y el tratamiento potencial con anticoagulantes.

Palabras clave:
sondas de unión a fibrinaenfermedad de Alzheimerneuroimagenologíadetección tempranaestado pro-trombóticoanticoagulantesbiomarcadores de imagenacumulación de fibrinaterapias personalizadas

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Área de la Ciencia:

  • Neurociencia
  • Desarrollo de biomarcadores
  • Imagenología médica

Sus antecedentes:

  • La enfermedad de Alzheimer (EA) es la demencia más común, caracterizada por una compleja neuropatología.
  • Un estado pro-trombótico, que conduce a la acumulación de fibrina en los vasos cerebrales, está implicado en la patogénesis de la EA.
  • La detección temprana de este estado procoagulante puede permitir una intervención oportuna con terapias anticoagulantes.

Objetivo del estudio:

  • Desarrollar biomarcadores de imagen novedosos para detectar de forma no invasiva el estado procoagulante en la EA.
  • Utilizar sondas de unión a fibrina (FBPs) para identificar la acumulación de fibrina cerebral.
  • Establecer estrategias de neuroimagen para el diagnóstico temprano de la EA y el tratamiento personalizado.

Principales métodos:

  • El proyecto BioClotAD emplea ensayos in vitro, ex vivo e in vivo en múltiples sitios europeos.
  • Se prueban sondas de unión a fibrina (FBPs) para la detección in vivo de oclusiones cerebrales mediante imagen nuclear.
  • Se desarrollan FBPs acoplados a un anticuerpo del receptor de transferrina (FBP-TfR) para mejorar la penetración de la barrera hematoencefálica (BBB) para la imagen óptica y nuclear.

Principales resultados:

  • Se desarrollaron estrategias factibles de neuroimagen para detectar la acumulación de fibrina in vivo en modelos de EA.
  • Se identificó la distribución regional de la deposición de fibrina cerebral en la EA.
  • El estudio sienta las bases para futuros ensayos clínicos sobre la neuroimagen de la acumulación de fibrina cerebral en la EA.

Conclusiones:

  • Los biomarcadores de neuroimagen de BioClotAD facilitan la detección temprana del estado pro-trombótico en la EA.
  • Esta detección temprana abre oportunidades para terapias anticoagulantes personalizadas para retrasar la progresión de la enfermedad.
  • Los biomarcadores desarrollados representan un paso significativo hacia una mejor gestión de la EA.