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Salud Pública

Jason R Richardson1, Isha Mhatre-Winters1, Piera Cirillo2

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Resumen
Este resumen es generado por máquina.

La exposición prenatal al metabolito del pesticida DDT, DDE, se relacionó con niveles más bajos de un biomarcador clave de Alzheimer y una peor función cognitiva en la mediana edad. Esto sugiere que la exposición a DDT/DDE puede aumentar el riesgo de Alzheimer y Demencias Relacionadas (ADRD).

Palabras clave:
Salud PúblicaExposición PrenatalDDECogniciónAlzheimer

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Área de la Ciencia:

  • Salud Ambiental; Neurociencia; Toxicología

Sus antecedentes:

  • Las exposiciones ambientales son cada vez más reconocidas como factores de riesgo para el Alzheimer y las Demencias Relacionadas (ADRD).; Investigaciones previas vincularon niveles más altos de DDE en suero (un metabolito persistente del DDT) con un mayor riesgo de Alzheimer y deterioro cognitivo.; Estudios en animales muestran que el DDT/DDE reduce la función cognitiva y aumenta la patología amiloide, indicada por una menor relación Aβ 42/40 en plasma.

Objetivo del estudio:

  • Investigar los efectos de la exposición prenatal a DDE en los niveles de amiloide-beta (Aβ) en plasma y la función cognitiva en humanos.; Evaluar la asociación entre la exposición prenatal a DDE y el rendimiento cognitivo y la relación Aβ 42/40 en plasma en la mediana edad.

Principales métodos:

  • Se utilizaron datos de la cohorte de embarazo del Child Health and Development Studies (CHDS) (1959-1963).; Se evaluó la función cognitiva en la mediana edad utilizando la prueba de dígitos de símbolos (DSST) y se midió la relación Aβ 42/40 en plasma en 179 participantes.; Se midieron los niveles de p,p'-DDE prenatal en suero materno archivado y se analizaron las asociaciones utilizando modelos de regresión lineal generalizada.

Principales resultados:

  • Los niveles de p,p'-DDE prenatal se asociaron significativamente con una menor relación Aβ 42/40 en plasma en la mediana edad (β = -0.37, p = 0.03).; Niveles más altos de p,p'-DDE prenatal se correlacionaron con un peor rendimiento en el DSST en la mediana edad (β = -0.020, p = 0.02).; Estas asociaciones se mantuvieron robustas después de ajustar por covariables.

Conclusiones:

  • La exposición prenatal a p,p'-DDE se asocia con alteraciones en los niveles de Aβ 42/40 y deterioro de la función cognitiva en la mediana edad.; La identificación de poblaciones con mayor exposición a DDT/DDE puede ayudar a identificar a personas con mayor riesgo de ADRD.; Se pueden desarrollar estrategias tempranas de intervención y prevención para aquellos en riesgo de progresión de ADRD.