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Salud Pública

Pei-Chuan Ho1, Boon Lead Tee2, Clara Li3

  • 1University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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|December 23, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La Cohorte Asiática para la Enfermedad de Alzheimer (ACAD) reclutó con éxito a más de 1100 asiático-americanos y asiático-canadienses para la investigación de la enfermedad de Alzheimer. Este estudio destaca métodos culturalmente sensibles para involucrar a poblaciones diversas en la investigación de la demencia.

Palabras clave:
Salud PúblicaEnfermedad de AlzheimerInvestigación GenéticaEstudios de CohorteInvestigación Participativa Basada en la ComunidadAsiático-AmericanosAsiático-CanadiensesProtocolos Culturalmente Sensibles

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Área de la Ciencia:

  • Neurociencia; Genética; Salud Pública

Sus antecedentes:

  • Los asiático-americanos y asiático-canadienses (ASAC) son el grupo minoritario de más rápido crecimiento en los EE. UU. y Canadá. Los ASAC están subrepresentados en la investigación de la enfermedad de Alzheimer (AD), lo que requiere enfoques culturalmente apropiados. La Cohorte Asiática para la Enfermedad de Alzheimer (ACAD) se estableció para abordar esta brecha, centrándose en las poblaciones china, coreana y vietnamita.

Objetivo del estudio:

  • Investigar los factores de riesgo genéticos y no genéticos para la AD entre los ASAC. Desarrollar e implementar protocolos clínicos culturalmente apropiados y estrategias de reclutamiento basadas en la comunidad. Establecer la primera cohorte grande de genética de demencia para estos grupos étnicos asiáticos específicos.

Principales métodos:

  • La ACAD se expandió a 9 sitios de reclutamiento con un sistema centralizado de gestión de datos después de recibir una subvención U19 del NIA. El protocolo del estudio se actualizó basándose en los comentarios de la fase piloto, incluyendo cuestionarios culturalmente adaptados y recopilación de datos multilingüe (inglés, chino, coreano, vietnamita). Se implementó un plan de estudios de capacitación integral para el reclutamiento y la recopilación de datos/muestras culturalmente apropiados.

Principales resultados:

  • A enero de 2025, la ACAD ha dado su consentimiento a 1173 participantes, con 1920 adicionales en la lista de interesados. Las visitas de seguimiento están programadas para comenzar en la primavera de 2025 para rastrear la conversión y progresión de la demencia. Se ha desarrollado un protocolo de recopilación de datos culturalmente apropiado, adecuado tanto para evaluaciones presenciales como virtuales.

Conclusiones:

  • El equipo de la ACAD ha demostrado la viabilidad de reclutar ASAC en entornos de investigación clínica. Los planes de expansión y las colaboraciones con otras iniciativas de investigación de AD centradas en minorías tienen como objetivo identificar vías terapéuticas específicas de la población para la AD. Las ideas de la ACAD pueden conducir a tratamientos novedosos adaptados para poblaciones diversas afectadas por la enfermedad de Alzheimer.