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Primary Healthcare Services01:30

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Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
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Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
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Preventive Healthcare Services01:30

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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
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Methods Of Healthcare Delivery System01:26

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At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Salud Pública

Ingryd Mayara Nascimento Martins-Pais1, Carlos Fermín-Martínez2, Omar Bello-Chavolla3

  • 1Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
Resumen

Una mayor edad biológica, medida por AntropoEdad, se asocia con un peor rendimiento cognitivo en adultos mayores a nivel mundial. Esta asociación no fue mediada por la proteína Klotho, lo que sugiere que pueden estar involucrados otros factores.

Palabras clave:
edad biológicaAntropoEdaddeterioro cognitivoadultos mayoresKlothoenvejecimientocognición

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Área de la Ciencia:

  • Gerontología
  • Neurociencia Cognitiva
  • Biomarcadores del Envejecimiento

Sus antecedentes:

  • La edad cronológica es un factor de riesgo principal para el deterioro cognitivo, pero no representa completamente las complejidades del envejecimiento.
  • AntropoEdad, una métrica novedosa de edad biológica que utiliza datos antropométricos, predice mejor la mortalidad que la edad cronológica.
  • Se está investigando el papel de la proteína antienvejecimiento Klotho en el envejecimiento y su posible mediación de los efectos del envejecimiento en la cognición.

Objetivo del estudio:

  • Investigar la asociación entre AntropoEdad y el rendimiento cognitivo en diversas poblaciones de adultos mayores.
  • Determinar si la proteína antienvejecimiento Klotho media la relación entre AntropoEdad y la función cognitiva.

Principales métodos:

  • Se utilizaron datos de adultos mayores (≥60 años) de múltiples cohortes internacionales (NHANES, HRS-HCAP, ELSA-HCAP, LASI-DAD, Mex-Cog).
  • Se empleó una métrica simplificada de AntropoEdad (edad, IMC, relación cintura-altura) para evaluar la edad biológica.
  • Se evaluó el rendimiento cognitivo a través de la memoria, la función ejecutiva y la fluidez verbal, y se analizaron las asociaciones utilizando regresión lineal y análisis de mediación con Klotho.

Principales resultados:

  • El análisis incluyó a más de 7.500 participantes de cinco cohortes internacionales.
  • Una mayor edad biológica (AntropoEdad) se asoció significativamente con un peor rendimiento cognitivo en todos los países evaluados.
  • La asociación entre AntropoEdad y el rendimiento cognitivo no fue mediada por los niveles de Klotho.

Conclusiones:

  • Una edad biológica elevada, indicada por AntropoEdad, se correlaciona con una disminución del rendimiento cognitivo en adultos mayores.
  • Los dominios cognitivos específicos afectados variaron según el país, lo que resalta los patrones de envejecimiento específicos de la población.
  • Klotho no parece mediar el vínculo entre AntropoEdad y el deterioro cognitivo, lo que sugiere vías alternativas.