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Solo el 6% de todos los pacientes y el 15% con deterioro cognitivo leve o enfermedad de Alzheimer cumplieron los criterios de elegibilidad para terapias anti-amiloides (AAT). Este estudio evaluó la elegibilidad para AAT en una clínica de memoria, proporcionando datos cruciales para la preparación del sistema de salud y análisis de costos.

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Área de la Ciencia:

  • Neurología
  • Farmacología
  • Biomarcadores

Sus antecedentes:

  • Las recientes aprobaciones de terapias anti-amiloides (AAT) para la enfermedad de Alzheimer (AD) requieren la evaluación de la elegibilidad de los pacientes.
  • Los datos del mundo real sobre la elegibilidad de AAT, estimados en 1-18% según biomarcadores, siguen siendo limitados.
  • Este estudio evaluó la elegibilidad de AAT en una clínica de memoria terciaria utilizando los criterios de lecanemab (2020-2022).

Objetivo del estudio:

  • Determinar la proporción de pacientes en una clínica de memoria terciaria elegibles para terapias anti-amiloides (AAT).
  • Evaluar la elegibilidad según los criterios establecidos para la enfermedad de Alzheimer (AD) y el deterioro cognitivo leve (MCI).
  • Proporcionar datos para la preparación del sistema de salud y análisis de impacto presupuestario de las AAT.

Principales métodos:

  • Se estudiaron 1309 pacientes del Centro de Alzheimer de Ámsterdam (2020-2022) que se sometieron a un diagnóstico estándar.
  • Los criterios de elegibilidad incluyeron diagnóstico clínico de MCI/AD, CDR 0.5-1.0, MMSE 22-27, positividad para amiloide y <4 microhemorragias.
  • Los criterios de exclusión incluyeron homocigosidad APOE ε4/ε4 y uso de anticoagulantes.

Principales resultados:

  • De 1309 pacientes, 514 tenían MCI o AD; 196 cumplieron los criterios CDR/MMSE.
  • 158 eran positivos para amiloide, 25 tenían estado desconocido; 108 cumplieron los criterios de biomarcadores (8% de todos los pacientes).
  • Después de las exclusiones, 79 pacientes (6% de todos los pacientes, 15% de MCI/AD) eran elegibles para AAT.

Conclusiones:

  • En una clínica de memoria terciaria, el 8% de todos los pacientes y el 21% con MCI/AD cumplieron los criterios para AAT.
  • Los hallazgos son cruciales para la planificación del sistema de salud y las evaluaciones económicas de las AAT.
  • Este estudio proporciona datos del mundo real sobre la elegibilidad de AAT en un entorno clínico.