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Salud Pública

Thanapoom Taweephol1, Thanakit Pongpitakmetha2,3,4,5, Akarin Hiransuthikul6

  • 1Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

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|December 23, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los determinantes sociales de la salud influyen significativamente en la resiliencia cognitiva en la población tailandesa. Factores como la educación y la actividad física promueven la resiliencia, mientras que fumar y estar sentado durante mucho tiempo la disminuyen.

Palabras clave:
determinantes sociales de la saludresiliencia cognitivapoblación tailandesap-tau217salud pública

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Área de la Ciencia:

  • Neurociencia; Salud Pública; Gerontología

Sus antecedentes:

  • Los determinantes sociales de la salud (SDOH) son cruciales para la resiliencia cognitiva en diversas poblaciones, incluidas aquellas con enfermedad de Alzheimer (EA).
  • El p-tau217 fosforilado en plasma (p-tau217) sirve como un biomarcador específico de la patología y gravedad de la EA.
  • Es esencial comprender el impacto de los SDOH en la resiliencia cognitiva en la población tailandesa.

Objetivo del estudio:

  • Investigar los factores que contribuyen a la resiliencia cognitiva en la población tailandesa.
  • Analizar la relación entre los determinantes sociales de la salud y la resiliencia cognitiva, utilizando los niveles de p-tau217 en plasma y las puntuaciones cognitivas.

Principales métodos:

  • Inscripción prospectiva en la cohorte INDE del Hospital King Chulalongkorn Memorial, Bangkok, Tailandia.
  • Recopilación de datos clínicos, pruebas neuropsicológicas y niveles de p-tau217 en plasma.
  • Se utilizaron modelos de regresión para definir la resiliencia cognitiva (residuos de las puntuaciones MoCA y p-tau217) e identificar los factores SDOH asociados, ajustados por edad y sexo.

Principales resultados:

  • Entre 297 participantes, el 55,9% presentó una alta resiliencia cognitiva.
  • Un valor de propiedad más alto (>10 millones de baht), un mayor nivel educativo y el cumplimiento de las recomendaciones de actividad física se relacionaron con una mayor resiliencia cognitiva.
  • Una mayor distancia de la ciudad, el tabaquismo actual, una mayor duración del sueño y más tiempo de sedentarismo diario se asociaron con una menor resiliencia cognitiva.

Conclusiones:

  • Los determinantes sociales de la salud modulan significativamente la resiliencia cognitiva, como lo indican el p-tau217 y las puntuaciones cognitivas.
  • Son necesarias intervenciones clínicas y políticas públicas que aborden los SDOH para mejorar la resiliencia cognitiva, especialmente en países de ingresos bajos y medianos (PIMB).