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Salud Pública

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El estudio Impact of Intensive Treatment of Systolic Blood Pressure (IPAT) encontró que las bases de datos hospitalarias fueron las más efectivas para el reclutamiento. Muchas personas interesadas fueron excluidas debido a una presión arterial sistólica (PAS) inferior a 130 mmHg.

Palabras clave:
hipertensiónensayos clínicosreclutamiento de pacientesadultos mayoressalud pública

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Área de la Ciencia:

  • Neurología
  • Medicina Cardiovascular
  • Ensayos Clínicos

Sus antecedentes:

  • El estudio Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid, and Tau (IPAT) investiga los efectos del tratamiento intensivo de la presión arterial.
  • Este ensayo controlado aleatorio se dirige a adultos mayores (60-85 años) con hipertensión (PAS > 130 mmHg).
  • Su objetivo es evaluar los impactos en la amiloide y la tau cerebral utilizando tomografía por emisión de positrones (PET).

Objetivo del estudio:

  • Evaluar la efectividad de las estrategias de reclutamiento del estudio IPAT.
  • Identificar las principales razones de exclusión de los participantes durante la inscripción.
  • Optimizar el reclutamiento futuro para ensayos clínicos que involucren hipertensión.

Principales métodos:

  • El reclutamiento utilizó bases de datos hospitalarias (MyChart), correos electrónicos de marketing y eventos de extensión comunitaria.
  • Se evaluaron 1735 personas por teléfono y 140 dieron su consentimiento durante dos años (octubre de 2022 - noviembre de 2024).
  • Los criterios de exclusión involucraron principalmente la presión arterial sistólica (PAS) < 130 mmHg y la incapacidad para someterse a escáneres de RM/PET.

Principales resultados:

  • Las bases de datos hospitalarias produjeron la tasa de aleatorización más alta (31%).
  • Las principales razones de exclusión incluyeron PAS < 130 mmHg (390 evaluados, 13 consentidos) y falta de interés del participante (254 evaluados).
  • Los participantes que consintieron eran predominantemente blancos no hispanos (80%) con educación superior (88%).

Conclusiones:

  • Las bases de datos hospitalarias son efectivas para reclutar para el estudio IPAT.
  • Las estrategias actuales pueden reclutar en exceso a personas con presión arterial bien controlada.
  • El reclutamiento futuro debe dirigirse a poblaciones desatendidas con acceso limitado al manejo de la presión arterial, como comunidades minoritarias o rurales.