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Synthetic Biology02:55

Synthetic Biology

5.5K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
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Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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Cis-regulatory Sequences02:02

Cis-regulatory Sequences

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Cis-regulatory Sequences02:02

Cis-regulatory Sequences

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DNA as a Genetic Template02:05

DNA as a Genetic Template

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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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DNA as a Genetic Template02:05

DNA as a Genetic Template

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Updated: Jan 8, 2026

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
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Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

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Diseño de elementos regulatorios sintéticos utilizando el marco de IA generativa DNA-Diffusion

Lucas Ferreira DaSilva1,2, Simon Senan2,3, Judith F Kribelbauer-Swietek4,5,6

  • 1Department of Pathology, Harvard Medical School, Boston, MA, USA.

Nature genetics
|December 24, 2025
PubMed
Resumen
Este resumen es generado por máquina.

DNA-Diffusion, un marco de IA, diseña elementos regulatorios génicos compactos con actividad específica del tipo celular. Esto avanza en biología sintética y terapias génicas al permitir un control génico preciso.

Palabras clave:
Inteligencia artificial generativaBiología sintéticaElementos regulatorios génicosTerapias génicasEdición génicaGenómicaDiseño de ADN

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Área de la Ciencia:

  • Genómica
  • Biología sintética
  • Inteligencia artificial

Sus antecedentes:

  • El control preciso de la expresión génica a través de elementos regulatorios es un desafío clave.
  • Los métodos existentes luchan por equilibrar la actividad funcional, la especificidad del tipo celular y la diversidad de secuencias.

Objetivo del estudio:

  • Introducir DNA-Diffusion, un marco de IA generativa para diseñar nuevos elementos regulatorios.
  • Lograr un control de la expresión génica específico del tipo celular con elementos sintéticos compactos.

Principales métodos:

  • Desarrolló DNA-Diffusion, un marco de IA entrenado en datos de accesibilidad del ADN.
  • Generó elementos sintéticos de 200 pares de bases que imitan la unión del factor de transcripción endógeno.
  • Validó los elementos utilizando STARR-seq en tres líneas celulares y EXTRA-seq para la modulación de genes endógenos.

Principales resultados:

  • DNA-Diffusion generó elementos compactos con especificidad mejorada del tipo celular.
  • Los elementos sintéticos recapitularon la gramática de unión del factor de transcripción endógeno.
  • Reactiva con éxito el gen AXIN2 en su contexto nativo, demostrando modulación funcional.

Conclusiones:

  • DNA-Diffusion supera a los métodos computacionales existentes en el diseño de elementos regulatorios.
  • Este marco es crucial para la ingeniería de la regulación génica precisa en terapias génicas.
  • Permite avances en la comprensión de la regulación génica y el desarrollo de estrategias terapéuticas novedosas.