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Updated: Jan 8, 2026

08:06
Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test
Published on: January 15, 2010
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Desacoplamiento corticoestriatal específico del comportamiento y del tipo celular en un modelo de ratón similar a la
Xu-Ran Yao1,2, Yang Liu1,2, Wei-Tong Zheng1,2
1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 24, 2025
Resumen
La enfermedad de Parkinson (EP) causa un desacoplamiento corticoestriatal temprano, que altera los comportamientos motores. Este problema de coordinación de la actividad cerebral, relacionado con las MSN de D1R, puede ser rescatado por la activación del receptor D1 o L-DOPA.
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