Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Safety considerations of gene-based therapies for Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Development and validation of a harmonized memory score for multicenter Alzheimer's disease and related dementia research.

Alzheimer's research & therapy·2026
Same author

Recommendations for genetic counseling for individuals at risk of autosomal dominant Alzheimer's disease in Latin America.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Regulatory Variation at TERT and TERC Shows Limited Association with Early-Onset Alzheimer's Disease in Carriers of the Mexican Founder Mutation <i>PSEN1</i> A431E.

Medical sciences (Basel, Switzerland)·2026
Same author

Elevated levels of circulating plasma sPDGFRβ in cognitively impaired APOE4 carriers.

GeroScience·2026
Same author

Regulatory Variants in the KRAS 3'UTR and Intron 2 Are Associated with Breast Cancer Susceptibility Through Independent and Combinatorial Effects in a Mexican Population.

Biomedicines·2026

Video Experimental Relacionado

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

Ciencia Básica y Patogénesis

Frida Rosales-Leycegui1, Angélica Zuno-Reyes1, César A Valdez-Gaxiola2

  • 1Instituto de Neurociencias, CUCBA, Universidad de Guadalajara, Guadalajara, JA, Mexico.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
Resumen

Los portadores de mutaciones de la enfermedad de Alzheimer de herencia autosómica dominante (ADAD) muestran déficits tempranos de memoria visual antes de que surjan síntomas clínicos. La variante génica APOE ε4 no pareció empeorar el rendimiento de la memoria en este estudio preclínico de ADAD.

Palabras clave:
memoria visualAlzheimerpreclínicoAPOE ε4ADAD

Más Videos Relacionados

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Videos de Experimentos Relacionados

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Área de la Ciencia:

  • Neurociencia
  • Genética
  • Psicología Cognitiva

Sus antecedentes:

  • La enfermedad de Alzheimer de herencia autosómica dominante (ADAD) ofrece información sobre los cambios cognitivos tempranos de la enfermedad de Alzheimer (AD).
  • El papel de APOE ε4 en la AD esporádica está establecido, pero su impacto en los fenotipos cognitivos de la ADAD no está claro.

Objetivo del estudio:

  • Investigar el efecto de la coexistencia de APOE ε4 con las mutaciones APPV717I o PSEN1A431E en la función cognitiva preclínica de la ADAD.
  • Determinar si mutaciones específicas y APOE ε4 influyen en el rendimiento cognitivo en individuos en riesgo de ADAD.

Principales métodos:

  • Se realizaron análisis genéticos (mutaciones APPV717I/PSEN1A431E, genotipado de APOE) y evaluación neuropsicológica (CERAD-MX) en 81 individuos mexicanos-mestizos.
  • Los participantes se clasificaron en portadores de mutaciones (C) y no portadores (NC), y se estratificaron además por estado de APOE ε4 (ε4+/ε4-).
  • Se evaluó el rendimiento cognitivo utilizando puntuaciones z normalizadas en 12 tareas del CERAD-MX, y las diferencias grupales se analizaron mediante pruebas no paramétricas.

Principales resultados:

  • Los portadores de mutaciones (C) demostraron un rendimiento significativamente menor en tareas de memoria visual (Praxis de Construcción-Recuerdo, Figura Compleja de Rey-Osterrieth-Recuerdo) en comparación con los no portadores (NC).
  • Dentro de los portadores de mutaciones, aquellos sin el alelo APOE ε4 (Cε4-) mostraron un peor rendimiento en la Figura Compleja de Rey-Osterrieth-Recuerdo en comparación con los no portadores sin el alelo APOE ε4 (NCε4-).

Conclusiones:

  • El deterioro temprano de la memoria visual es detectable en la etapa preclínica de la ADAD.
  • El alelo APOE ε4 no mostró un efecto perjudicial en el rendimiento de la memoria en esta cohorte de ADAD.
  • Se necesita más investigación con tamaños de muestra más grandes para confirmar los hallazgos y explorar otros dominios cognitivos y factores influyentes como la ascendencia de APOE.