Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Current Advancement and Patient Outcomes in Reperfusion Brain Injuries After Stroke: A Comparative Analysis of Thrombolysis and Thrombectomy.

Brain and behavior·2025
Same author

Exploring the emigration intentions of Nigerian medical and nursing students: factors driving migration and implications for Nigeria's healthcare system.

BMC medical education·2025
Same author

Exploring burnout in medical education: a mixed-method study among university of Ibadan medical students.

BMC medical education·2025
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

Ciencia básica y patogénesis

Henry Demian Oyoyo1,2,3,4, Jonas Ibekwe2,3,4, Chukwuebuka Stanley Asogwa2,4,5

  • 1Mission Brain Ibadan, Ibadan, Oyo - State, Nigeria.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los exosomas derivados de la microbiota influyen en la enfermedad de Alzheimer (EA) y la demencia al modular la neuroinflamación y la dinámica del amiloide beta. Dirigirse a estos exosomas ofrece estrategias terapéuticas potenciales para enfermedades neurodegenerativas.

Palabras clave:
exosomasmicrobiotaenfermedad de Alzheimerdemencianeuroinflamaciónamiloide betaeje intestino-cerebroneurodegeneraciónterapiasbiomarcadores

Más Videos Relacionados

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Videos de Experimentos Relacionados

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Área de la Ciencia:

  • Neurociencia
  • Microbiología
  • Bioquímica

Sus antecedentes:

  • La enfermedad de Alzheimer (EA) y la demencia son trastornos neurodegenerativos progresivos que afectan la función cognitiva.
  • El eje microbiota-intestino-cerebro juega un papel crucial en la salud cerebral, con exosomas derivados de la microbiota mediando la comunicación intercelular.
  • Los exosomas de los microbios intestinales influyen en la neuroinflamación, la dinámica del amiloide beta y la neuroprotección, afectando potencialmente la patología de la EA.

Objetivo del estudio:

  • Explorar cómo los exosomas derivados de la microbiota influyen en la progresión de la enfermedad de Alzheimer y la demencia.
  • Evaluar el potencial terapéutico de los exosomas derivados de la microbiota en el manejo de enfermedades neurodegenerativas.
  • Sintetizar la evidencia sobre los mecanismos por los cuales los exosomas modulan la neuroinflamación y la neurodegeneración.

Principales métodos:

  • Se realizó una búsqueda bibliográfica exhaustiva en PubMed, Cochrane library y Scopus.
  • Las palabras clave incluyeron microbiota, exosomas, enfermedad de Alzheimer, demencia, eje intestino-cerebro y neurodegeneración.
  • Se seleccionaron estudios basados en la relevancia y la calidad de la evidencia.

Principales resultados:

  • Los exosomas derivados de la microbiota pueden cruzar la barrera hematoencefálica, modulando la activación de la microglía y las respuestas inflamatorias.
  • Estos exosomas impactan la agregación y depuración del amiloide beta, contribuyendo a la patología de la EA.
  • Los exosomas derivados de la microbiota muestran potencial como biomarcadores para la detección y el seguimiento tempranos de la EA.

Conclusiones:

  • Los exosomas derivados de la microbiota son importantes para comprender la progresión de la EA y la demencia.
  • El eje intestino-cerebro, influenciado por estos exosomas, ofrece vías terapéuticas prometedoras para enfermedades neurodegenerativas.
  • Se necesita más investigación para dilucidar los mecanismos y traducir los hallazgos en aplicaciones clínicas.