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Unlike direct titration, back-titration, and displacement titration, indirect titration is an EDTA titration method for quantifying anions. In the indirect titration method, anions are precipitated as their insoluble salts with excess metal ions. The filtrate containing the excess metal ions is directly titrated with standard EDTA until the endpoint is achieved. Another approach involves extracting the metal ion and back-titrating with standard EDTA to obtain the endpoint. In this way, the...
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Most acid-base titrations are performed in an aqueous medium. In aqueous titrations, water competes with weaker acids or bases for proton donation or acceptance, leading to ambiguous endpoints in the titration curve. Water also affects the partial ionization of weak acids or bases. For example, water accepts a proton from acetic acid to form hydronium and acetate ions. The hydronium ion formed is a stronger acid than acetic acid, and the acetate ion is a stronger base than water. As a result,...
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Coulometric titrations are a form of titrimetric analysis where the reagent is generated electrically, and its amount is evaluated based on current and generating time. The electron serves as the standard reagent. The procedure is similar to conventional titrations, such as endpoint detection.
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Hot Biological Catalysis: Isothermal Titration Calorimetry to Characterize Enzymatic Reactions
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Titulación sin red de seguridad

Seung Eun Lee1, Michael Mathis, Milisa Manojlovich

  • 1Seung Eun Lee is an associate professor at Yonsei University College of Nursing, Seoul, Republic of Korea, and a visiting scholar at the University of Michigan School of Nursing, Ann Arbor. Michael Mathis is an associate professor of anesthesiology at the University of Michigan Medical School, Ann Arbor. Milisa Manojlovich is a professor at the University of Michigan School of Nursing, Ann Arbor. Contact author: Seung Eun Lee, leese@yuhs.ac. The authors have disclosed no potential conflicts of interest, financial or otherwise.

The American journal of nursing
|December 24, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Las enfermeras de la unidad de cuidados intensivos (UCI) requieren protocolos basados en evidencia para la administración de medicamentos vasoactivos. Este estudio proporciona una guía crítica para optimizar la titulación de estos potentes fármacos en entornos de cuidados intensivos.

Palabras clave:
enfermería de cuidados intensivosmedicamentos vasoactivostitulaciónprotocoloscuidados intensivos

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Área de la Ciencia:

  • Medicina de Cuidados Intensivos
  • Farmacología
  • Ciencia de la Enfermería

Sus antecedentes:

  • Los medicamentos vasoactivos son esenciales para el manejo hemodinámico en las unidades de cuidados intensivos (UCI).
  • Las prácticas actuales para la titulación de fármacos vasoactivos carecen de directrices estandarizadas y basadas en evidencia.
  • Las estrategias de titulación inconsistentes pueden conducir a resultados subóptimos para los pacientes y a un aumento de los eventos adversos.

Objetivo del estudio:

  • Desarrollar y presentar recomendaciones basadas en evidencia para la titulación de medicamentos vasoactivos en la UCI.
  • Proporcionar una guía clara y procesable para las enfermeras de la UCI que atienden a pacientes críticamente enfermos que requieren soporte hemodinámico.
  • Mejorar la seguridad y la eficacia de la terapia con fármacos vasoactivos.

Principales métodos:

  • Revisión sistemática de la literatura existente sobre el uso y la titulación de medicamentos vasoactivos.
  • Proceso de desarrollo de consenso que involucra a expertos en cuidados intensivos y enfermeras de la UCI.
  • Análisis de datos farmacocinéticos y farmacodinámicos de agentes vasoactivos de uso común.

Principales resultados:

  • Se identificaron parámetros clave para iniciar y ajustar las infusiones vasoactivas.
  • Se propusieron algoritmos de titulación específicos basados en evidencia para fármacos vasoactivos comunes (por ejemplo, norepinefrina, dopamina, dobutamina).
  • Las recomendaciones abordan los objetivos hemodinámicos y las estrategias de monitorización.

Conclusiones:

  • La guía estandarizada y basada en evidencia para la titulación de medicamentos vasoactivos es crucial para las enfermeras de la UCI.
  • La implementación de estas recomendaciones puede mejorar la atención al paciente y la toma de decisiones clínicas.
  • La investigación futura debe centrarse en la validación prospectiva de estos protocolos de titulación.