Video Experimental Relacionado
Updated: Jan 8, 2026
09:07
Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
Published on: June 14, 2020
11.5K
Ciencia básica y patogénesis
Anna L Tyler1, Dylan Garceau1, Kevin P Kotredes1
1The Jackson Laboratory, Bar Harbor, ME, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
Resumen
La variante protectora VS de Klotho (KL) en ratones influye en la expresión génica relacionada con la función sináptica y la traducción de proteínas, ofreciendo información sobre los mecanismos del envejecimiento y la enfermedad de Alzheimer (EA).
Área de la Ciencia:
- Neurociencia; Genética; Investigación sobre el envejecimiento
Sus antecedentes:
- El haplotipo VS de Klotho (KL) está relacionado con un menor riesgo y patología de la enfermedad de Alzheimer (EA).; Se introdujeron variantes del gen KL humano (FC común y VS protector) en ratones para estudiar sus efectos relacionados con la EA.
Objetivo del estudio:
- Investigar el impacto de las variantes del gen Klotho humano (KL) en la patología de la enfermedad de Alzheimer (EA).; Establecer un modelo de ratón traslacional para estudiar el papel de KL en el envejecimiento y la EA.
Principales métodos:
- Se generaron ratones homocigotos y heterocigotos para las variantes del gen KL humano (FC y VS) junto con el tipo salvaje (FS).; Se midió la expresión génica en todo el cerebro a los 4 y 12 meses para identificar genes con expresión diferencial.
Principales resultados:
- No se observaron diferencias en la expresión génica a los 4 meses.; A los 12 meses, se identificaron 609 genes con expresión diferencial, enriquecidos para la función sináptica y la traducción de proteínas.; El alelo protector VS moduló genes relacionados con la sinapsis y la traducción/ribosomas.
Conclusiones:
- Las variantes humanas de KL en ratones proporcionan un modelo valioso para comprender el papel de KL en el envejecimiento y la EA.; Estos hallazgos resaltan la influencia de KL en las vías sinápticas y de traducción relevantes para la neurodegeneración.
Videos de Conceptos Relacionados
01:20Infection
11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
01:25Urinary Tract Infection II: Pathophysiology
524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
01:23Cystic Fibrosis: Pathogenesis
676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
01:29Pneumonia II: Pathophysiology
2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
01:26Stages of Infection
64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
01:31Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K