Video Experimental Relacionado
Updated: Jan 8, 2026
09:07
Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
Published on: June 14, 2020
11.5K
Ciencia básica y patogénesis
Diede Broekaart1, Abhijeet Sharma1, Aarthi Ramakrishnan1
1Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
Resumen
Las neuronas excitatorias son las más vulnerables a la patología tau en las tauropatías. La alteración de la neurotransmisión y los cambios sinápticos, posiblemente impulsados por Mef2c, contribuyen a esta vulnerabilidad selectiva y a la neurodegeneración.
Área de la Ciencia:
- Neurociencia
- Biología Molecular
- Genética
Sus antecedentes:
- Las tauropatías implican la agregación de la proteína tau hiperfosforilada, lo que conduce al deterioro cognitivo.
- La tau patológica se disemina a través de regiones cerebrales y tipos neuronales específicos, pero los mecanismos de vulnerabilidad selectiva no están claros.
Objetivo del estudio:
- Investigar los mecanismos celulares y moleculares subyacentes a la vulnerabilidad neuronal selectiva en tauropatías.
- Identificar los actores moleculares clave que contribuyen a la susceptibilidad regional a la patología tau.
Principales métodos:
- Inmunohistoquímica en tejido cerebral humano post-mortem de tauropatías.
- Purificación de ribosomas de traducción viral (vTRAP) en ratones P301S (PS19) y controles.
- Secuenciación de ARN, bioinformática (Gene Ontology, MECT) y caracterización electrofisiológica.
Principales resultados:
- Las neuronas excitatorias muestran una acumulación predominante de tau en comparación con las neuronas inhibitorias en diversas tauropatías.
- Las neuronas y regiones vulnerables presentan alteración de la transmisión sináptica y la excitabilidad neuronal.
- Se identificó Mef2c como regulador de la mielinización y la organización sináptica en regiones vulnerables; hallazgos validados en tauropatías humanas.
Conclusiones:
- Las neuronas excitatorias son el objetivo principal de la patología tau en las tauropatías.
- La vulnerabilidad selectiva está relacionada con la alteración de la neurotransmisión y la composición sináptica, potencialmente regulada por Mef2c.
- Este estudio dilucida los impulsores moleculares de la susceptibilidad regional y celular en la neurodegeneración.
Videos de Conceptos Relacionados
01:20Infection
11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
01:25Urinary Tract Infection II: Pathophysiology
524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
01:23Cystic Fibrosis: Pathogenesis
676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
01:29Pneumonia II: Pathophysiology
2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
01:26Stages of Infection
64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
01:31Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K