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Updated: Jul 18, 2026

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Diseño Racional de Lípidos Modificados con 3α-Amino Litocolato con Conmutación de pH para la Entrega Eficiente de

Xueying Gu1, Yunfeng Han1, Wenfeng Liu2

  • 1State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, P. R. China.

Advanced healthcare materials
|December 24, 2025
PubMed
Resumen

Lípidos novedosos sensibles al pH mejoran la entrega de ARN al mejorar el escape endosómico. Estas nanopartículas lipídicas (LNPs) modificadas muestran una promesa para la próxima generación de terapias, superando un desafío clave en la entrega citosólica.

Palabras clave:
entrega de fármacosescape endosómicosilenciamiento génicolípido amino ionizablenanopartícula lipídicasiRNA

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