Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Erratum to "Links between COVID-19, long COVID, and neurodegeneration: The role of glycosphingolipids" [Pharmacological Reviews 78 (2026) 100113].

Pharmacological reviews·2026
Same author

An efficient step-by-step approach to select pleiotropic drug candidates against Alzheimer's disease: The discovery of neocopride.

Journal of Alzheimer's disease : JAD·2026
Same author

Links between COVID-19, long COVID, and neurodegeneration: The role of glycosphingolipids.

Pharmacological reviews·2026
Same author

Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations.

Nature communications·2026
Same author

A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia.

Brain : a journal of neurology·2025
Same author

AZP2006 in Progressive Supranuclear Palsy: Outcomes from a Phase 2a Multicenter, Randomized Trial, and Open-Label Extension on Safety, Biomarkers, and Disease Progression.

Movement disorders : official journal of the Movement Disorder Society·2025

Video Experimental Relacionado

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

Ciencia básica y patogénesis

Noelle Callizot1, Laura Rouvière1, Catherine Botto1

  • 1Neuro-Sys, Gardanne, France.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
Resumen

Las enfermedades neurodegenerativas implican agregados de proteínas como la beta amiloide (Aβ), la tau hiperfosforilada (pTau) y la alfa-sinucleína (αSyn). Este estudio muestra que estas proteínas pueden desencadenarse mutuamente.

Palabras clave:
agregados de proteínasenfermedades neurodegenerativastaualfa-sinucleínabeta amiloide

Más Videos Relacionados

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Videos de Experimentos Relacionados

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Área de la Ciencia:

  • Neurociencia
  • Biología Molecular
  • Patología

Sus antecedentes:

  • Las enfermedades neurodegenerativas a menudo presentan agregados de proteínas coexistentes, lo que sugiere vínculos moleculares.
  • Si bien se conocen las interacciones entre la beta amiloide (Aβ), la tau hiperfosforilada (pTau) y la alfa-sinucleína (αSyn), los vínculos directos en la formación de agregados no están claros.
  • Comprender el acoplamiento mecanicista y la patogenicidad de estas interacciones proteicas es crucial.

Objetivo del estudio:

  • Investigar los vínculos directos entre la formación de agregados de Aβ, pTau y αSyn.
  • Explorar la aparición secuencial y la autoinducción de estos agregados de proteínas tóxicas en la neurodegeneración.
  • Elucidar el papel del estrés oxidativo y la disfunción lisosomal en este proceso.

Principales métodos:

  • Se trataron cultivos primarios de neuronas (hipocampales y dopaminérgicas) con oligómeros de Aβ o fibrillas preformadas de αSyn (PFF).
  • Se evaluó el estrés mitocondrial y lisosomal, junto con la acumulación de proteínas.
  • Se inyectaron ratones de edad avanzada con Aβ o PFF de αSyn por vía estereotáxica, con análisis posterior de la agregación de proteínas en varias regiones del cerebro.

Principales resultados:

  • Se observó una fuerte correlación entre los agregados tóxicos de αSyn y la acumulación de pTau.
  • Se detectó αSyn agregado después de inyecciones de Aβ en el hipocampo.
  • La aparición de estos agregados tóxicos fue consistentemente precedida por un estrés oxidativo significativo y defectos lisosomales.

Conclusiones:

  • Estos hallazgos resaltan la compleja interacción entre Aβ, pTau y αSyn en la neurodegeneración.
  • El estudio demuestra que estas proteínas pueden interactuar físicamente y, lo que es importante, inducir la formación de cada una.
  • Esta autoinducción contribuye a la muerte neuronal, lo que subraya un mecanismo patogénico crítico.